filament shaped

Edge evidence

• DivIVA localizes to apical polarisome biolink:located_in

  DivIVA localizes at hyphal tips as part of the polar growth machinery.

  • DOI:10.1016/j.mib.2010.10.002 polarity determinant DivIVA Supports DivIVA as a polarity determinant in Streptomyces.
• Scy enables apical polarisome RO:0002327

  Scy is a component of the tip-organizing center controlling polar growth.

  • DOI:10.1371/journal.pgen.1002423 tip organizing center Supports Scy/DivIVA assemblies in Streptomyces polarized growth.
• apical polarisome recruits apical peptidoglycan synthesis

  The apical polarisome recruits cell-wall synthesis machinery to hyphal tips.

  • DOI:10.1016/j.mib.2012.10.012 polarisome-like complex involving the essential polarity protein DivIVA Supports polarisome-directed apical growth and cell-wall assembly.
• apical peptidoglycan synthesis regulates hyphal tip extension RO:0002211

  Localized wall synthesis at the tip drives filament extension.

  • DOI:10.1038/s41564-025-02080-x DivIVA drives growth at the hyphal poles Supports DivIVA-recruited PG synthesis at hyphal poles.
• hyphal tip extension manifests as filament shaped METPO:2007400

  Hyphal tip extension manifests filamentous morphology.

  • DOI:10.1016/j.mib.2010.10.002 Streptomyces hyphae Supports filamentous hyphal morphology as the trait endpoint.
• RecA/LexA SOS response induces SulA

  DNA damage activates the RecA/LexA SOS response, inducing the division inhibitor SulA.

  • DOI:10.1002/advs.202203260 DNA damage activates the RecA/LexA SOS response, leading to expression of sulA.
• SulA inhibits FtsZ polymerization RO:0002212

  SulA blocks FtsZ polymerization, preventing Z-ring assembly and septation.

  • DOI:10.1002/advs.202203260 A cell division inhibitor, sulA, blocks FtsZ / SulA interferes with FtsZ polymerization.
• FtsZ polymerization regulates filament shaped RO:0002211

  Inhibited FtsZ polymerization blocks septation, causing non-septate filamentation.

  • DOI:10.1002/advs.202203260 FtsZ inhibition / blocked septation contributes to non-septate cellular filamentation.
• apical polarisome enables polar hyphal growth RO:0002327

  The DivIVA/polarisome assembly mediates polar growth at hyphal tips.

  • DOI:10.1128/jb.00153-23 Hyphal growth occurs at the tips of the filamentous cells; this polar growth is mediated by DivIVA.
• apical polarisome promotes hyphal branch emergence RO:0002213

  Splitting of polarisomes at tips produces daughter polarisomes that coordinate new branch emergence.

  • DOI:10.1093/femsml/uqad020 DivIVA forms discrete foci at growing tips; splitting of polarisomes produces daughter polarisomes coordinating emergence of new branches.
• CglA enables cell-wall glycopolymer attachment RO:0002327

  CglA is the glycopolymer ligase mediating attachment of glycopolymers to the cell wall.

  • DOI:10.1128/mbio.01492-24 Identified the LCP-LytR_C domain protein CglA as a key glycopolymer ligase.
• cell-wall glycopolymer attachment regulates filament shaped RO:0002211

  Reduced glycopolymer attachment results in enlarged vegetative hyphae and loss of hyphal cell shape.

  • DOI:10.1128/mbio.01492-24 Reduced amount of glycopolymers in the cglA mutant results in enlarged vegetative hyphae.