helical shaped

Edge evidence

• Csd shape proteins promotes peptidoglycan crosslink relaxation RO:0002213

  Csd peptidoglycan endopeptidase homologs contribute to reduced crosslinking in helical-shape generation.

  • DOI:10.1016/j.cell.2010.03.046 three LytM peptidoglycan endopeptidase homologs Supports Csd proteins as required genes in the H. pylori helical shape pathway.
• CcmA contributes to peptidoglycan crosslink relaxation RO:0002326

  CcmA contributes to the shape-generating pathway for helical morphology.

  • DOI:10.1016/j.cell.2010.03.046 three LytM peptidoglycan endopeptidase homologs ... and a ccmA homolog Supports CcmA as one of the proteins required for helical shape.
• peptidoglycan crosslink relaxation enables helical curvature and twist RO:0002327

  Relaxed peptidoglycan crosslinking enables curvature and twist.

  • DOI:10.1016/j.cell.2010.03.046 relaxes peptidoglycan crosslinking, enabling helical cell curvature and twist Direct evidence for PG crosslink relaxation causing helical geometry.
• helical curvature and twist produces helical shaped METPO:2000202

  Helical curvature and twist produce the helical-shaped trait.

  • DOI:10.1016/j.cell.2010.03.046 helical cell curvature and twist Supports the morphology endpoint of the graph.
• peptidoglycan DL-carboxypeptidase activity causes peptidoglycan stem peptide trimming biolink:causes

  DL-carboxypeptidase activity trims monomeric tripeptides to dipeptides in the peptidoglycan stem.

  • DOI:10.1371/journal.ppat.1002602 Pgp1 is a novel peptidoglycan DL-carboxypeptidase cleaving monomeric tripeptides to dipeptides.
• peptidoglycan stem peptide trimming promotes helical shaped RO:0002213

  Peptidoglycan stem peptide trimming supports generation of the helical cell shape.

  • DOI:10.1371/journal.ppat.1002602 Pgp1 DL-carboxypeptidase activity on peptidoglycan stem peptides is required for helical cell shape.
• loss of peptidoglycan-modifying enzyme causes rod-shaped morphology biolink:causes

  Loss of a peptidoglycan-modifying enzyme produces a straight rod-shaped morphology.

  • DOI:10.1371/journal.ppat.1002602 Deletion of pgp1 resulted in a striking, rod-shaped morphology.
• rod-shaped morphology negatively regulates helical shaped

  Rod-shaped morphology represents loss of the helical-shaped trait.

  • DOI:10.1371/journal.ppat.1002602 pgp1 deletion converts helical cells to rod-shaped cells, i.e., loss of helical shape.
• localized peptidoglycan crosslink hydrolysis enables helical curvature and twist RO:0002327

  Localized peptidoglycan crosslink hydrolysis generates the curvature and twist underlying helical shape.

  • DOI:10.1016/j.cell.2010.03.046 Coordinated action of multiple proteins relaxes peptidoglycan crosslinking, enabling helical cell curvature and twist.