irregular shaped

Edge evidence

• reduced cell-wall patterning enables stochastic growth RO:0002327

  Reduced patterning permits stochastic growth-zone placement.

  • DOI:10.1146/annurev-cellbio-101011-155745 cell shape is genetically determined Supports patterning loss as a driver of inconsistent shapes.
• stochastic growth produces variable cell geometry METPO:2000202

  Stochastic growth produces variable cell geometry.

  • DOI:10.1111/j.1574-6976.2011.00298.x coryneform morphology Supports irregular coryneform-like morphology arising from polar/apical growth without strong lateral patterning.
• variable cell geometry manifests as irregular shaped METPO:2007400

  Variable geometry across cells manifests the irregular-shaped trait.

  • DOI:10.1146/annurev-cellbio-101011-155745 cell shape is genetically determined Supports the trait endpoint.
• loss of MreB function disrupts MreB cytoskeletal function

  Inhibition or depletion of MreB removes curvature sensing and localized cell-wall insertion control.

  • DOI:10.1101/2024.11.22.624946 MreB filaments sense curvature and direct localized cell-wall insertion; A22 inhibition of MreB polymerization alters width and causes rounding/loss of rod shape.
• loss of MreB function causes irregular shaped biolink:causes

  Loss of MreB-mediated localized PG insertion removes rod-shape maintenance, yielding rounding and heterogeneous morphologies.

  • DOI:10.1101/2024.11.22.624946 Inhibition of MreB polymerization causes rounding/loss of rod shape across model bacteria; a broadly conserved shape-maintenance module.
• peptidoglycan synthase-hydrolase imbalance contributes to reduced cell-wall patterning RO:0002326

  Loss of coordination between peptidoglycan synthases and hydrolases degrades spatial control of wall synthesis.

  • DOI:10.1038/s41467-023-41082-3 Coordinated peptidoglycan synthases and hydrolases stabilize the bacterial cell wall; uncoupling them (e.g. excess hydrolase activity) accelerates loss of regular shape as a general loss-of-patterning mechanism.
• perturbation of polar growth determinants disrupts polarized growth organization

  Disruption of apical polar growth determinants disorganizes the tip-organizing center and wall-synthesis focusing.

  • DOI:10.21203/rs.3.rs-3811693/v1 Apical determinants stabilize the tip-organizing center; their perturbation is associated with abnormal branching and mispatterned wall synthesis in filamentous bacteria.
• perturbation of polar growth determinants produces variable cell geometry METPO:2000202

  Mispatterned apical wall synthesis from disrupted polar growth produces irregular, branched/bulged geometry.

  • DOI:10.21203/rs.3.rs-3811693/v1 Partial depletion of the polar scaffold DivIVA causes hyphal bulging and irregular branching, an irregular-shape outcome of disorganized polar growth.
• wall-less (L-form) state manifests as irregular shaped METPO:2007400

  Absence of a cylindrical wall removes canonical shape constraints, yielding irregular, amoeboid morphology.

  • DOI:10.1038/s42003-024-07279-y Wall-less L-form cells have heterogeneous, amoeboid morphology; loss of the rigid wall removes shape constraints, a general consequence of wall absence.