spirochete shaped

Edge evidence

• FlaB builds periplasmic flagella biolink:produces

  FlaB is required for periplasmic flagellar filaments.

  • DOI:10.1073/pnas.200221797 gene encoding the major periplasmic flagellar filament protein FlaB Targeted mutagenesis of flaB removed periplasmic flagella in Borrelia burgdorferi.
• periplasmic flagella interact with cell cylinder biolink:interacts_with

  Periplasmic flagella interact with the cell cylinder to deform the spirochete body.

  • DOI:10.1073/pnas.200221797 complex interaction between the cell cylinder and the internal periplasmic flagella Supports a physical interaction between flagella and cell cylinder.
• periplasmic flagella confers flat-wave morphology

  Periplasmic flagella provide a skeletal function that confers flat-wave morphology.

  • DOI:10.1073/pnas.200221797 have a skeletal function Supports periplasmic flagella as morphology-shaping structures.
• flat-wave morphology produces spirochete shaped METPO:2000202

  Flat-wave or helical deformation produces spirochete morphology.

  • DOI:10.1073/pnas.200221797 cell morphology is either a helix, a flat wave, or an irregularly shaped helix Supports spirochete-shape classes and their dependence on internal flagella-cell-body geometry.
• periplasmic flagella distort and push cell body deformation

  Periplasmic flagella enclosed in the periplasm distort and push the cell body by flagellar motor action.

  • DOI:10.1093/pnasnexus/pgad349 spirochete flagella are enclosed in the periplasmic space and the filaments distort and push the cell body by action of the flagellar motors
• cell body deformation produces spirochete shaped METPO:2000202

  Flagella-driven cell body deformation produces the helical or flat-wave spirochete morphology.

  • DOI:10.1093/pnasnexus/pgad349 Endoflagella-driven distortion of the cell body underlies spirochete shape.
• FlhE prevents ectopic periplasmic filament assembly RO:0002212

  FlhE prevents ectopic assembly of flagellar filaments in the periplasm.

  • DOI:10.1038/s41467-024-50278-0 FlhE is a periplasmic, Sec-translocated protein that prevents ectopic assembly of flagellar filaments in the periplasm.
• ectopic periplasmic filament assembly mislocalizes divisome and elongasome localization

  Ectopic periplasmic filament assembly mislocalizes divisome and elongasome complexes required for peptidoglycan synthesis.

  • DOI:10.1038/s41467-024-50278-0 periplasmic filament assembly causally mis-localizes divisome and elongasome complexes required for peptidoglycan synthesis
• divisome and elongasome localization alters spirochete shaped

  Mislocalized divisome/elongasome alters cell curvature and rod morphology, coupling periplasmic filaments to envelope shape.

  • DOI:10.1038/s41467-024-50278-0 producing altered cell curvature/loss of rod morphology and infrequent cell lysis
• FlgV modulates periplasmic flagella RO:0002211

  FlgV localizes to the flagellar basal body and modulates periplasmic flagellar filament assembly.

  • DOI:10.1038/s41467-024-54806-w FlgV localizes to the flagellar basal body and altering FlgV levels profoundly impacts filament assembly
• FlgV perturbs cell division and morphology

  Reduced or aberrant FlgV levels perturb cell division and cell morphology in spirochetes.

  • DOI:10.1038/s41467-024-54806-w ΔflgV mutants exhibit defects in cell division and motility, including conjoined spirochetes; overproduction leads to cell elongation