coccus shaped

Edge evidence

• FtsZ division ring recruits penicillin-binding proteins

  FtsZ-associated division machinery recruits cell-wall enzymes for septal synthesis in cocci.

  • DOI:10.1038/nrmicro3088 one type of cell wall synthesis machinery Review describes coccal growth as relying on division-septum wall synthesis machinery.
• penicillin-binding proteins catalyzes septal peptidoglycan synthesis biolink:catalyzes

  PBPs catalyze peptidoglycan assembly at the septum.

  • DOI:10.1038/nrmicro3088 catalysed by one type of cell wall synthesis machinery Supports wall-synthesis enzymes as the proximal machinery for septal peptidoglycan synthesis in spherical cocci.
• septal peptidoglycan synthesis regulates coccus shaped RO:0002211

  Septum-centered peptidoglycan synthesis supports spherical coccus morphology.

  • DOI:10.1038/nrmicro3088 synthesize peptidoglycan only at the division septum Supports septal-only wall synthesis as a mechanism for spherical coccal growth.
• lateral cell-wall elongation reduced in coccus shaped

  Cocci lack the sustained lateral elongation mode that produces rod morphology.

  • DOI:10.1038/nrmicro3088 round, rod-shaped, curved and spiral cells Review contrasts mechanisms for cocci with rod-shaped lateral growth; edge is retained as a broad mechanistic distinction rather than a universal gene-loss claim.
• peripheral peptidoglycan synthesis negatively associated with coccus shaped

  Peripheral/mid-cell wall synthesis drives elongation away from true spherical coccus morphology.

  • DOI:10.1038/nrmicro3088 Pinho 2013: ovococci perform both septal and peripheral peptidoglycan synthesis; peripheral synthesis drives slight longitudinal elongation and the ovoid shape, distinguishing it from true cocci.
• divisome complex mediates septal peptidoglycan synthesis

  Divisome-centered machinery mediates peptidoglycan synthesis at the septum in cocci.

  • DOI:10.1042/BSR20221664 Battaje 2023: in cocci, peptidoglycan synthesis takes place mostly at the site of division, i.e. the septum coordinated by FtsZ via the divisome complex.
• FtsZ division ring coordinates septal peptidoglycan synthesis

  FtsZ coordinates septal peptidoglycan synthesis, linking the cytoskeletal ring to coccal septal growth.

  • DOI:10.1042/BSR20221664 Battaje 2023: peptidoglycan synthesis takes place mostly at the septum coordinated by FtsZ; broad across bacteria, especially cocci.
• coccus shaped associated with orthogonal division planes biolink:associated_with

  Spherical cocci alternate division in two or three orthogonal planes.

  • DOI:10.1038/nrmicro3088 Pinho 2013: spherical cocci can alternate division in two or three orthogonal planes; a morphology-associated arrangement behavior.
• peripheral peptidoglycan synthesis produces ovococcal/ovoid shape METPO:2000202

  Peripheral synthesis between equatorial rings produces ovococcal/ovoid shape, a boundary contrast to true cocci.

  • DOI:10.1038/nrmicro3088 Pinho 2013: peripheral synthesis occurring at mid-cell, between the equatorial rings, drives slight longitudinal elongation and the ovoid shape.