aerobic

Edge evidence

• aerobic depends on molecular oxygen RO:0002502

  Aerobic growth depends on molecular oxygen availability.

  • DOI:10.1016/j.celrep.2023.112444 obligate aerobe ... exposed to hypoxia, stops growing Mycobacterium tuberculosis example supports oxygen dependence for aerobic growth.
• aerobic has mechanistic process aerobic respiration

  The aerobic trait is mechanistically tied to oxygen-dependent respiration.

  • DOI:10.1016/j.bbabio.2011.06.016 respiratory quinol:O2 oxidoreductase Review supports oxygen-reducing terminal oxidases as core aerobic respiratory enzymes.
• aerobic respiration depends on molecular oxygen RO:0002502

  Aerobic respiration requires oxygen.

  • DOI:10.1016/j.celrep.2023.112444 transfer electrons from the ETC to O2 Supports molecular oxygen as the terminal acceptor for bacterial respiratory electron transport.
• molecular oxygen acts as terminal electron acceptor

  In aerobic energy metabolism, molecular oxygen acts as the terminal electron acceptor.

  • DOI:10.1016/j.celrep.2023.112444 terminal oxidases transfer electrons from the ETC to O2 Supports oxygen's electron-acceptor role in terminal oxidase activity.
• substrate dehydrogenases transfers electrons to quinone pool METPO:2007403

  Substrate dehydrogenases pass electrons to the membrane quinone pool in the respiratory chain.

  • DOI:10.1128/ecosalplus.esp-0012-2015 Electrons are transferred from substrate-specific dehydrogenases to a quinone pool (menaquinone, ubiquinone, dimethylmenaquinone).
• quinone pool transfers electrons to terminal oxidases METPO:2007403

  Reduced quinol is oxidized by terminal oxidases that reduce O2 to water.

  • DOI:10.1128/ecosalplus.esp-0012-2015 Quinol-to-O2 oxidation is catalyzed by quinol oxidases (cytochrome bo3, cytochrome bd) reducing O2 to H2O.
• terminal oxidases reduces molecular oxygen METPO:2000017

  Terminal oxidases catalyze the four-electron reduction of O2 to water.

  • DOI:10.3390/antiox13030383 Terminal oxidases catalyze the four-electron reduction of O2 to water and generate the proton motive force for ATP.
• terminal oxidases generates proton motive force biolink:produces

  Respiratory terminal oxidases generate the proton motive force.

  • DOI:10.3390/antiox13030383 Terminal oxidases catalyze reduction of O2 to water and generate the proton motive force for ATP.
• proton motive force powers ATP synthesis

  The transmembrane electrochemical gradient powers ATP synthesis.

  • DOI:10.1038/s41579-021-00583-y The transmembrane electrochemical gradient powers the membrane proteins that synthesize ATP.
• aerobic respiration generates reactive oxygen species biolink:produces

  Aerobic respiration produces ROS endogenously via respiratory flavoproteins.

  • DOI:10.30970/sbi.1702.716 ROS are formed endogenously during aerobic respiration due to activity of respiratory flavoproteins.
• ROS-scavenging enzymes detoxifies reactive oxygen species

  SODs, catalases and peroxidases eliminate reactive oxygen species, enabling aerobic growth.

  • DOI:10.30970/sbi.1702.716 Elimination of radicals via ROS-scavenging enzymes: superoxide dismutases (SODs), catalases and peroxidases.