alkalotolerant

Edge evidence

• alkaline exposure challenges alkalotolerant METPO:2007406

  Alkalotolerance reflects capacity to withstand alkaline pH outside the growth optimum.

  • DOI:10.1016/j.bbamem.2005.09.010 alkali-tolerant and extremely alkaliphilic bacteria Review explicitly covers alkali-tolerant bacteria.
• alkaline exposure challenges cytoplasmic pH homeostasis METPO:2007406

  Alkaline pH requires maintenance of a less alkaline cytoplasm.

  • DOI:10.1038/nrmicro2549 grow in environments with external pH values Review supports pH homeostasis for growth outside cytoplasmic pH range.
• proton retention contributes to cytoplasmic pH homeostasis RO:0002326

  Proton capture and retention support pH homeostasis in alkaline environments.

  • DOI:10.1016/j.bbamem.2005.09.010 promote proton capture and retention Supports proton retention mechanisms during alkaline pH challenge.
• cation/proton antiporter contributes to cytoplasmic pH homeostasis RO:0002326

  Cation/proton antiporters help regulate intracellular pH under alkaline stress.

  • DOI:10.3390/ijms21124566 maintaining ion and pH homeostasis Supports cation/proton antiporters as pH-homeostasis transporters.
• cytoplasmic pH homeostasis enables alkalotolerant RO:0002327

  Alkaline tolerance depends on maintaining cytoplasmic pH during alkaline exposure.

  • DOI:10.1038/nrmicro2549 cell-wide physiological process Supports pH homeostasis as a broad enabling process.
• alkaline external pH increases importance of electrogenic Na+/H+ antiport

  Alkaline extracellular pH makes electrogenic Na+/H+ antiport particularly important for proton import.

  • DOI:10.3390/ijms23169156 Negative-inside membrane potential drives Na+ extrusion, particularly important when extracellular pH is alkaline (general prokaryotic mechanism).
• acidic non-peptidoglycan cell-surface polymers helps maintain cytoplasmic pH homeostasis

  Acidic non-peptidoglycan polymers create surface negative charges that reduce pH at the cell surface and help keep intracellular pH near neutrality.

  • DOI:10.1007/978-4-431-55408-0_4 Acidic non-peptidoglycan polymers create negative charges that reduce pH at the cell surface and help keep intracellular pH controlled.
• acidic non-peptidoglycan cell-surface polymers adsorbs sodium and hydronium ions

  Negatively charged cell-surface polymers adsorb sodium and hydronium ions.

  • DOI:10.1128/MMBR.63.4.735-750.1999 Cell surface acidic polymers adsorb sodium and hydronium ions; cell-envelope charge chemistry mechanism.
• acidic non-peptidoglycan cell-surface polymers repels hydroxide ion

  Negatively charged cell-surface polymers repel hydroxide ions, mitigating alkaline stress at the surface.

  • DOI:10.1128/MMBR.63.4.735-750.1999 Acidic non-peptidoglycan polymers repulse hydroxide ions at the cell surface.
• sodium motive force supports cytoplasmic pH homeostasis

  A sodium motive force mediated by Na+/H+ antiporters and related proteins supports intracellular pH control.

  • DOI:10.1007/s11244-024-01919-7 Sodium motive force mediated by Na+/H+ antiporters, Na+ channels or stator proteins supports intracellular pH control (review-level, broad).