Druantia III system

traitmech:000560 · CLASS · PROPOSED

A Druantia system in which an organism possesses a genome-encoded DefenseFinder Druantia_III subtype locus represented by the Druantia_III rule row requiring both the Druantia_III__DruH and Druantia__DruE_1 profiles.

Trait evidence (7)

DOI:10.64898/2026.05.12.724681
Druantia III is a late-acting defence where DruH is the likely infection sensor and DruE is a helicase-nuclease effector that engages ssDNA-containing replication intermediates

Wu et al. support the characterized Druantia III arrangement in which DruH likely senses infection and DruE acts as the helicase-nuclease effector.
DOI:10.64898/2026.05.12.724681
we identified 6,885 bacterial genomes encoding complete Druantia III systems, defined by the presence of both DruE and DruH

Wu et al. support Druantia III as a recurring bacterial DruE/DruH system rather than a single engineered locus.
https://pmc.ncbi.nlm.nih.gov/articles/PMC12458937/
Screening 66 phages that could form plaques on the double-deletion strain showed that the strain carrying only Druantia III exhibited at least modest protection (<0.01 EOP or <0.5 SFC) against 3 phages, whereas the strain carrying ARMADA Type II exhibited a much broader range of immunity, with at least modest protection observed against 30 phages.

Bell et al. support native E. coli ATCC 8739 Druantia III protection in a deletion-resolved panel separating Druantia III from co-located ARMADA Type II activity.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md
| Druantia | 10\.1126/science\.aar4120 | Systematic discovery of antiphage defense systems in the microbial pangenome |

The pinned DefenseFinder article registry maps the broad Druantia model namespace to the Doron et al. microbial pangenome antiphage-system discovery paper.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md
| Druantia__DruE_1 | Druantia__DruE_1 | Druantia | Custom | 20 |

The pinned DefenseFinder HMM inventory records the shared Druantia__DruE_1 custom profile listed by the Druantia_III rule row.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md
| Druantia_III__DruH | Druantia_III__DruH | Druantia_III | Custom | 20 |

The pinned DefenseFinder HMM inventory records the Druantia_III__DruH custom profile under the Druantia_III model namespace.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv
Druantia Druantia_III 2 2 Druantia_III__DruH, Druantia__DruE_1

The pinned DefenseFinder rules table models Druantia_III as a Druantia subsystem requiring two mandatory matches from Druantia_III__DruH and Druantia__DruE_1 and two genes overall.

Druantia III loci mark a DruH-dependent Druantia subtype

Conservative subtype-level sketch linking a DefenseFinder Druantia_III locus to DruE/DruH-dependent Type III Druantia DNA processing, Druantia III system possession, and its Druantia parent.

NONMECHANISTIC · The graph captures the Druantia_III subtype at DefenseFinder rule-row level without resolving the exact late phage trigger, DruH sensory intermediate, RecBCD dependence, Zorya II synergy, native host breadth beyond the E. coli ATCC 8739 observation, Type I, Type II, or Type IV partner functions, or whether every DefenseFinder Druantia_III prediction is a complete experimentally active locus.

Edge evidence

Druantia III locus contributes to Druantia III DruE/DruH DNA processing RO:0002326
Druantia_III loci are represented in DefenseFinder by Druantia_III__DruH and Druantia__DruE_1, and Wu et al. define complete Druantia III systems by the presence of both DruE and DruH.
- DOI:10.64898/2026.05.12.724681 we identified 6,885 bacterial genomes encoding complete Druantia III systems, defined by the presence of both DruE and DruH Wu et al. support Druantia III as a recurring bacterial DruE/DruH system rather than a single engineered locus.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md | Druantia__DruE_1 | Druantia__DruE_1 | Druantia | Custom | 20 | The pinned DefenseFinder HMM inventory records the shared Druantia__DruE_1 custom profile listed by the Druantia_III rule row.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md | Druantia_III__DruH | Druantia_III__DruH | Druantia_III | Custom | 20 | The pinned DefenseFinder HMM inventory records the Druantia_III__DruH custom profile under the Druantia_III model namespace.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv Druantia Druantia_III 2 2 Druantia_III__DruH, Druantia__DruE_1 The pinned DefenseFinder rules table models Druantia_III as a Druantia subsystem requiring two mandatory matches from Druantia_III__DruH and Druantia__DruE_1 and two genes overall.
Druantia III DruE/DruH DNA processing confers Druantia III system METPO:2007700
The first-pass Druantia III system trait is realized by a DruE/DruH locus whose late defense uses DruE helicase-nuclease effector activity.
- DOI:10.64898/2026.05.12.724681 Druantia III is a late-acting defence where DruH is the likely infection sensor and DruE is a helicase-nuclease effector that engages ssDNA-containing replication intermediates Wu et al. support the characterized Druantia III arrangement in which DruH likely senses infection and DruE acts as the helicase-nuclease effector.
Druantia III system is a Druantia system rdfs:subClassOf
Druantia III system possession is a Druantia-system trait.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md | Druantia | 10\.1126/science\.aar4120 | Systematic discovery of antiphage defense systems in the microbial pangenome | The pinned DefenseFinder article registry maps the broad Druantia model namespace to the Doron et al. microbial pangenome antiphage-system discovery paper.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv Druantia Druantia_III 2 2 The pinned DefenseFinder rules table places the Druantia_III subsystem under the Druantia system key with two mandatory matches and two genes required.

Provenance

Identifier source: TraitMech local identifier
Definition source: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv

Parent traits (1)

Druantia system traitmech:000234

Synonyms (4)

Druantia III EXACT_SYNONYM · DOI:10.64898/2026.05.12.724681
Druantia_III RELATED_SYNONYM · https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv
Druantia_III__DruH RELATED_SYNONYM · https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md
Druantia__DruE_1 RELATED_SYNONYM · https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md

kg-microbe context

No kg-microbe node embedding matched this record in the 2026-04-25 deepwalk.

Canonical examples (1)

Organisms cited as exemplars of this trait. Taxon ids are NCBITaxon and link out to the NCBI record.

Escherichia coli NCBITaxon:562 https://pmc.ncbi.nlm.nih.gov/articles/PMC12458937/ Bell et al. screened E. coli ATCC 8739 system-deletion derivatives and observed at least modest phage protection in the derivative retaining only the native Druantia III system.

Discussions and Knowledge Gaps (1)

Open questions attached to this trait. Seeded by just knowledge-gap-scan and curated; see the corpus-wide index.

Resolve Druantia_III phage triggers, DruH sensory chemistry, RecBCD and Zorya coupling, native host breadth, and profile-to-activity criteria before minting enzyme, trigger, or component children.

KNOWLEDGE GAP OPEN druantia-iii-activity-gap · raised by codex · 2026-10-03

Attached to causal_graphs#druantia_iii_locus_subtype_defense

Wu et al. support Druantia III as a recurring DruE/DruH system in which DruH is the likely infection sensor and DruE is a helicase-nuclease effector, and the pinned DefenseFinder HMM inventory and rules table support Druantia_III as a subtype whose rule row requires the Druantia_III__DruH and Druantia__DruE_1 profiles. Bell et al. support one deletion-resolved native E. coli ATCC 8739 Druantia III protection observation. This first-pass record leaves exact late phage triggers, DruH sensory intermediates, RecBCD dependence, Zorya II coupling, native host breadth beyond ATCC 8739, and profile-to-activity criteria unresolved.

Evidence

DOI:10.64898/2026.05.12.724681
Druantia III is a late-acting defence where DruH is the likely infection sensor and DruE is a helicase-nuclease effector that engages ssDNA-containing replication intermediates
https://pmc.ncbi.nlm.nih.gov/articles/PMC12458937/
Screening 66 phages that could form plaques on the double-deletion strain showed that the strain carrying only Druantia III exhibited at least modest protection (<0.01 EOP or <0.5 SFC) against 3 phages, whereas the strain carrying ARMADA Type II exhibited a much broader range of immunity, with at least modest protection observed against 30 phages.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md
| Druantia_III__DruH | Druantia_III__DruH | Druantia_III | Custom | 20 |
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv
Druantia Druantia_III 2 2 Druantia_III__DruH, Druantia__DruE_1

Curation history

2026-10-03T00:37:00Z · MINTED_TRAITMECH_ID · codex
Minted Druantia III system as a DOI- and DefenseFinder-backed GENOMICS TraitRecord under the Druantia system parent after an ignored-and-hidden duplicate review found no exact live TraitMech, METPO, history, or prior proposal record for the target local ID, placeholder METPO ID, proposal cohort, record slug, human label, DefenseFinder subsystem, DruH profile, or shared DruE_1 profile; existing Druantia III mentions were supporting evidence on broad Druantia or ARMADA records, not an exact child TraitRecord, and the replacement placeholder is reserved in proposals/metpo_traitmech_v437.
2026-10-03T00:37:02Z · REVIEW_CANONICAL_EXAMPLE · codex
Reviewed Druantia III system during initial curation and added Escherichia coli because Bell et al. reported a deletion-resolved E. coli ATCC 8739 derivative retaining only native Druantia III activity with modest protection against 3 of 66 screened phages. Broader native host breadth remains unresolved, and no paid research was used.