FS-HsdR-like system

traitmech:000350 · CLASS · PROPOSED

A phage defense system in which an organism possesses an FS_HsdR_like locus represented by DefenseFinder as a two-gene model drawing from custom FS_HsdR_like__DUF6731, FS_HsdR_like__HP, and FS_HsdR_like__HdrR profiles.

Trait evidence (7)

PMID:35985290
the phage-inducible chromosomal islands (PICIs), carry an impressive arsenal of defense mechanisms

Fillol-Salom et al. support phage-inducible chromosomal islands as carriers of mobile-element defense mechanisms.
PMID:35985290
These defense systems provide broad immunity, blocking not only phage reproduction, but also plasmid and non-cognate PICI transfer.

Fillol-Salom et al. support PICI-encoded defense systems as broad immunity determinants against phage reproduction and other mobile genetic element transfer.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md
FS_HsdR_like | 10\.1016/j\.cell\.2022\.07\.014 | Bacteriophages benefit from mobilizing pathogenicity islands encoding immune systems against competitors

The DefenseFinder article registry maps the named FS_HsdR_like system to the Fillol-Salom et al. PICI defense-system paper.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv
FS_HsdR_like FS_HsdR_like 2 2 FS_HsdR_like__DUF6731, FS_HsdR_like__HP, FS_HsdR_like__HdrR

The DefenseFinder rules table models FS_HsdR_like with two mandatory profiles selected from three custom DUF6731, HP, and HdrR profile keys.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md
| FS_HsdR_like__DUF6731 | FS_HsdR_like__DUF6731 | FS_HsdR_like | Custom | 20 |

The DefenseFinder HMM inventory records FS_HsdR_like__DUF6731 under FS_HsdR_like.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md
| FS_HsdR_like__HdrR | FS_HsdR_like__HdrR | FS_HsdR_like | Custom | 20 |

The DefenseFinder HMM inventory records FS_HsdR_like__HdrR under FS_HsdR_like.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md
| FS_HsdR_like__HP | FS_HsdR_like__HP | FS_HsdR_like | Custom | 20 |

The DefenseFinder HMM inventory records FS_HsdR_like__HP under FS_HsdR_like.

FS-HsdR-like loci confer bacterial phage defense

Conservative system-level sketch linking possession of an FS_HsdR_like locus to broad mobile-element defense without asserting the unresolved phage trigger or molecular output.

NONMECHANISTIC · The graph captures FS-HsdR-like as a named DefenseFinder two-gene system in the Fillol-Salom PICI defense family while leaving its natural host breadth, helper-phage trigger, DUF6731 component activity, HP component identity, HdrR component activity, and profile-to-activity mapping unresolved.

Edge evidence

FS_HsdR_like locus contributes to PICI-encoded mobile-element defense RO:0002326
DefenseFinder maps FS_HsdR_like to the Fillol-Salom et al. PICI-encoded immunity study and models it as a two-gene system selecting from custom DUF6731, HP, and HdrR profiles.
- PMID:35985290 the phage-inducible chromosomal islands (PICIs), carry an impressive arsenal of defense mechanisms Fillol-Salom et al. support PICI loci as carriers of phage and mobile-element defense mechanisms.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md FS_HsdR_like | 10\.1016/j\.cell\.2022\.07\.014 | Bacteriophages benefit from mobilizing pathogenicity islands encoding immune systems against competitors The DefenseFinder article registry maps the named FS_HsdR_like system to the Fillol-Salom et al. PICI defense-system paper.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv FS_HsdR_like FS_HsdR_like 2 2 FS_HsdR_like__DUF6731, FS_HsdR_like__HP, FS_HsdR_like__HdrR The DefenseFinder rules table models FS_HsdR_like with two mandatory profiles selected from three custom DUF6731, HP, and HdrR profile keys.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md | FS_HsdR_like__DUF6731 | FS_HsdR_like__DUF6731 | FS_HsdR_like | Custom | 20 | The DefenseFinder HMM inventory records FS_HsdR_like__DUF6731 under FS_HsdR_like.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md | FS_HsdR_like__HdrR | FS_HsdR_like__HdrR | FS_HsdR_like | Custom | 20 | The DefenseFinder HMM inventory records FS_HsdR_like__HdrR under FS_HsdR_like.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md | FS_HsdR_like__HP | FS_HsdR_like__HP | FS_HsdR_like | Custom | 20 | The DefenseFinder HMM inventory records FS_HsdR_like__HP under FS_HsdR_like.
PICI-encoded mobile-element defense confers FS-HsdR-like system METPO:2007700
FS_HsdR_like-associated mobile-element defense realizes the FS-HsdR-like system trait.
- PMID:35985290 These defense systems provide broad immunity, blocking not only phage reproduction, but also plasmid and non-cognate PICI transfer. Fillol-Salom et al. support PICI-encoded defense systems as broad mobile-element immunity determinants.
FS-HsdR-like system is a phage defense system rdfs:subClassOf
FS-HsdR-like system possession is a phage-defense-system trait.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md FS_HsdR_like | 10\.1016/j\.cell\.2022\.07\.014 | Bacteriophages benefit from mobilizing pathogenicity islands encoding immune systems against competitors The DefenseFinder article registry maps the named FS_HsdR_like system to the Fillol-Salom et al. PICI defense-system paper.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv FS_HsdR_like FS_HsdR_like 2 2 FS_HsdR_like__DUF6731, FS_HsdR_like__HP, FS_HsdR_like__HdrR The DefenseFinder rules table models FS_HsdR_like with two mandatory profiles selected from three custom DUF6731, HP, and HdrR profile keys.

Provenance

Identifier source: TraitMech local identifier
Definition source: DOI:10.1016/j.cell.2022.07.014

Parent traits (1)

phage defense system traitmech:000209

Synonyms (4)

FS_HsdR_like RELATED_SYNONYM · https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md
FS_HsdR_like__DUF6731 RELATED_SYNONYM · https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md
FS_HsdR_like__HdrR RELATED_SYNONYM · https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md
FS_HsdR_like__HP RELATED_SYNONYM · https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md

kg-microbe context

No kg-microbe node embedding matched this record in the 2026-04-25 deepwalk.

Discussions and Knowledge Gaps (1)

Open questions attached to this trait. Seeded by just knowledge-gap-scan and curated; see the corpus-wide index.

Resolve FS_HsdR_like natural hosts, helper-phage triggers, DUF6731 activity, HP component identity, HdrR activity, and the profile-to-activity mapping before minting narrower FS_HsdR_like mechanism children.

KNOWLEDGE GAP OPEN fs-hsdr-like-mechanism-gap · raised by codex · 2026-09-22

Attached to causal_graphs#fs_hsdr_like_locus_restricts_phage

Fillol-Salom et al. support phage-inducible chromosomal islands as carriers of defense systems that provide broad immunity, and DefenseFinder models FS_HsdR_like as a two-gene system drawing from three custom profile keys. Its exact natural host breadth, helper-phage trigger, component activities, and profile-to-activity mapping remain unresolved.

Curation history

2026-09-22T00:00:42Z · MINTED_TRAITMECH_ID · codex
Minted FS-HsdR-like system as a DOI-backed GENOMICS TraitRecord under phage defense system after an ignored-and-hidden duplicate review found no exact live TraitMech, METPO, history, or prior proposal record; the replacement placeholder is reserved in proposals/metpo_traitmech_v227.