Olokun system

traitmech:000254 · CLASS · PROPOSED

A phage defense system in which an organism possesses a two-component Olokun locus represented by OloA and OloB profiles that can protect bacteria from bacteriophage infection.

Trait evidence (6)

DOI:10.1016/j.chom.2022.09.017
discovery of 21 defense systems that protect bacteria from phages, based on computational genomic analyses and phage-infection experiments

Millman et al. report the computational and experimental cohort that DefenseFinder cites for Olokun as a bacterial anti-phage system.
DOI:10.1101/2022.05.11.491447
discovery of 21 new defense systems that protect bacteria from phages, based on computational genomic analyses and phage infection experiments

The bioRxiv version of Millman et al. independently carries the 21-system discovery claim linked from DefenseFinder's Olokun article registry.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md
Olokun | 10\.1101/2022\.05\.11\.491447 | An expanding arsenal of immune systems that protect bacteria from phages

The DefenseFinder model registry maps the named Olokun system to the Millman et al. antiphage-system discovery preprint.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv
Olokun Olokun 2 2 Olokun__OloA, Olokun__OloB

The DefenseFinder rules table models Olokun with OloA and OloB profiles.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md
Olokun__OloA | Olokun__OloA | Olokun

The DefenseFinder HMM inventory records OloA as an Olokun profile.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md
Olokun__OloB | Olokun__OloB | Olokun

The DefenseFinder HMM inventory records OloB as an Olokun profile.

Olokun loci confer bacterial phage defense

Conservative system-level sketch linking possession of an Olokun locus to restricted bacteriophage propagation without asserting the unresolved phage trigger or molecular output.

NONMECHANISTIC · The graph captures Olokun as a named anti-phage system with DefenseFinder OloA and OloB profile choices while leaving its phage trigger, molecular substrate, antiviral effector output, and subtype breadth unresolved.

Edge evidence

Olokun locus contributes to restricted phage propagation RO:0002326
DefenseFinder maps Olokun to a bacterial anti-phage-system discovery preprint and represents Olokun loci through OloA and OloB component profiles.
- DOI:10.1016/j.chom.2022.09.017 discovery of 21 defense systems that protect bacteria from phages Millman et al. describe the anti-phage discovery cohort that the DefenseFinder Olokun registry row maps to the Olokun system.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md Olokun | 10\.1101/2022\.05\.11\.491447 | An expanding arsenal of immune systems that protect bacteria from phages The DefenseFinder registry maps Olokun itself to the Millman et al. bacterial antiphage-system discovery preprint.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv Olokun Olokun 2 2 Olokun__OloA, Olokun__OloB The DefenseFinder rules table supports OloA and OloB as Olokun system profile choices.
restricted phage propagation confers Olokun system METPO:2007700
Olokun-mediated phage restriction realizes the Olokun system trait.
- DOI:10.1016/j.chom.2022.09.017 discovery of 21 defense systems that protect bacteria from phages Millman et al. place the Olokun discovery cohort in the set of bacterial systems that protect against phages.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md Olokun | 10\.1101/2022\.05\.11\.491447 | An expanding arsenal of immune systems that protect bacteria from phages DefenseFinder records Olokun as a named system from the Millman et al. antiphage discovery preprint.
Olokun system is a phage defense system rdfs:subClassOf
Olokun system possession is a phage-defense-system trait.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md An expanding arsenal of immune systems that protect bacteria from phages DefenseFinder associates Olokun with the Millman et al. bacterial antiphage-system discovery paper.

Provenance

Identifier source: TraitMech local identifier
Definition source: DOI:10.1016/j.chom.2022.09.017

Parent traits (1)

phage defense system traitmech:000209

Synonyms (1)

Olokun EXACT_SYNONYM · https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md

kg-microbe context

No kg-microbe node embedding matched this record in the 2026-04-25 deepwalk.

Discussions and Knowledge Gaps (1)

Open questions attached to this trait. Seeded by just knowledge-gap-scan and curated; see the corpus-wide index.

Resolve Olokun phage triggers and effector outputs before minting narrower Olokun mechanism children.

KNOWLEDGE GAP OPEN olokun-mechanism-gap · raised by codex · 2026-09-18

Attached to causal_graphs#olokun_locus_restricts_phage

Millman et al. and DefenseFinder support Olokun as a named anti-phage system with OloA and OloB profile choices, but the trigger, molecular substrate, antiviral effector output, and subtype-specific mechanism are not resolved enough here to assert a narrower mechanistic child trait.

Curation history

2026-09-18T22:52:00Z · MINTED_TRAITMECH_ID · codex
Minted Olokun system as a DOI-backed GENOMICS TraitRecord under phage defense system after an ignored-and-hidden duplicate review found no exact live TraitMech, METPO, or prior proposal record; the replacement placeholder is reserved in proposals/metpo_traitmech_v131.