lophotrichous

Edge evidence

• bacterial-type flagellum defines lophotrichous METPO:2007500

  A tuft of flagella at one pole defines the lophotrichous arrangement.

  • DOI:10.1093/femsre/fuv034 Schuhmacher et al. describe polar tufts of flagella (lophotrichous).
• lophotrichous associated with polar tuft placement biolink:associated_with

  The lophotrichous pattern places multiple flagella at one pole.

  • DOI:10.3390/biom9070279 Flagellum review supports multiple flagellar filaments acting as locomotory organelles.
• FlhF localizes to and promotes assembly at cell pole

  GTP-bound FlhF localizes to the cell pole and recruits initial flagellar building blocks.

  • DOI:10.7554/eLife.93004.3 GTP-bound dimeric FlhF localizes to the cell pole and recruits initial flagellar building blocks; deletion of flhF causes absence/mislocalization of flagella.
• FlhF recruits FliG

  FlhF binds the C-ring protein FliG to initiate polar assembly.

  • DOI:10.1038/s41467-024-50274-4 FlhF binds the C-ring protein FliG via its N-terminus.
• FliG captures FliF

  The FlhF:FliG complex recruits/captures FliF to promote MS-ring formation at the pole.

  • DOI:10.7554/eLife.93004.3 FliG captures FliF to promote MS-ring formation; recruits a functional FliF/FliG complex to the pole.
• FipA required for lophotrichous

  FipA is required for normal FlhF activity and polar flagellar synthesis.

  • DOI:10.7554/eLife.93004.3 FipA is required for normal FlhF activity and polar flagellar synthesis; deletion abolishes swimming motility and yields cells lacking surface flagella.
• FlhG negatively regulates flagellar number

  FlhG limits flagellar number; its loss causes hyper-flagellation.

  • DOI:10.1093/femsre/fuv034 Loss of FlhG causes hyper-flagellation; deletion of flhG produces hyper-flagellated strains.
• FlhG stimulates GTPase activity of FlhF

  FlhG stimulates the GTPase activity of FlhF, converting GTP-bound to GDP-bound FlhF.

  • DOI:10.1038/s41467-024-50274-4 FlhG stimulates the GTPase activity of the SRP-type GTPase FlhF, converting GTP-bound FlhF to GDP-bound FlhF.