cis-Golgi network

GO:0005801 · Membrane organelle · Membrane bounded organelle · Proposed

The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum. [GO:0005801]

Synonyms: cis Golgi network

Part of: Golgi apparatus (GO:0005794)

Has part: cis-Golgi network membrane (GO:0033106)

UniProt location names: UniProt Consortium, CC BY 4.0. Reference label and route sources.

Components

Component	Type	Part of / acts on	Grounding	Genes	Stoichiometry	Essential	Role
cis-Golgi network lipid bilayer	Lipid	part of	Reviewed label only (reviewed name; no accession asserted)			ESSENTIAL	Lipid-bilayer constituent of the cis-Golgi network membrane. `GO:0033106` GO:0033106 defines the cis-Golgi network membrane as the lipid bilayer around compartments that make up the cis-Golgi network.

Taxonomic distribution

NCBITaxon:4922 Komagataella pastoris — COMMON: Rossanese et al. resolved ordered Pichia pastoris Golgi stacks positioned near discrete transitional ER sites. [DOI:10.1083/jcb.145.1.69]

Canonical examples

NCBITaxon:4922 Komagataella pastoris — Budding-yeast model, originally studied as Pichia pastoris, with ordered Golgi stacks associated with transitional ER organization. [DOI:10.1083/jcb.145.1.69]

Mechanism graphs

Cis-Golgi networks occupy the ER-facing Golgi side (FUNCTION)

The cis-Golgi network is the membrane-bounded Golgi subcompartment on the Golgi side that abuts the endoplasmic reticulum.

Subject	Predicate	Object	Evidence
cis-Golgi network membrane	bounds	cis-Golgi network	`GO:0033106` GO:0033106 defines the membrane surrounding cis-Golgi network compartments.
cis-Golgi network	is part of	Golgi apparatus	`GO:0005801` GO:0005801 defines the cis-Golgi network as a network of tubular and cisternal structures on the convex side of the Golgi apparatus.
cis-Golgi network	abuts	endoplasmic reticulum	`GO:0005801` GO:0005801 places the cis-Golgi network on the Golgi side that abuts the endoplasmic reticulum. `DOI:10.1083/jcb.145.1.69` Rossanese et al. 1999 compared transitional-ER organization with Pichia and Saccharomyces Golgi organization.

Discussions

CURATION_TODO (OPEN): Resolve an exact source-neutral grounding for the lipid constituent of the cis-Golgi network membrane. The record is exactly grounded to GO:0005801 and GO:0033106 identifies the surrounding cis-Golgi network membrane, but the membrane lipid-bilayer constituent is intentionally left as reviewed-label-only until an exact source-neutral lipid or membrane-constituent CURIE is curated.
INTERPRETATION (RESOLVED): Keep Sed5p and transitional-ER/COPII traffic factors out of the cis-Golgi network structural-component list until exact source-neutral families are curated and a constituent-versus-trafficking boundary is reviewed. Rossanese et al. 1999 and Cho et al. 2000 support ER-proximal and Sed5p-positive early Golgi organization, but this initial cis-Golgi network record does not treat those trafficking factors as lipid-bilayer constituents of the cis-Golgi network itself.

Evidence

GO:0005801 Gene Ontology cellular-component term for cis-Golgi network.
GO:0098791 Gene Ontology cellular-component parent term for Golgi apparatus subcompartment.
GO:0005794 Gene Ontology cellular-component term for Golgi apparatus.
GO:0033106 Gene Ontology cellular-component term for cis-Golgi network membrane.
GO:0005783 Gene Ontology cellular-component term for endoplasmic reticulum.
DOI:10.1083/jcb.145.1.69 Rossanese et al. 1999, 'Golgi Structure Correlates with Transitional Endoplasmic Reticulum Organization in Pichia pastoris and Saccharomyces cerevisiae', Journal of Cell Biology.
DOI:10.1016/S0014-5793(00)01268-0 Cho, Noda and Yoda 2000, 'Proteins in the early golgi compartment of Saccharomyces cerevisiae immunoisolated by Sed5p', FEBS Letters.

Curation history

2026-09-14T05:13:12Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-14T05:14:54Z codex · EXPANDED_RECORD — Added Golgi-subcompartment parentage, Golgi-apparatus parthood, a GO:0033106 membrane part, a reviewed-label-only cis-Golgi lipid bilayer component, Komagataella scope, GO/DOI evidence, a nonmechanistic ER-adjacent entry graph, and lipid-grounding plus early-Golgi trafficking-factor boundary discussions.
2026-09-14T05:25:27Z codex · ADDRESS_REVIEW — Addressed #883 by removing the ad hoc ER-adjacent Golgi entry function and support edge so the causal graph only makes GO-backed cis-Golgi topology, membrane-boundary, and ER-adjacency claims.

Source: data/structures/membrane_organelle/cis_golgi_network.yaml