biosafety level 1

METPO:1001102 · CLASS · REVIEWED

A biosafety level that poses minimal potential hazard to laboratory workers and the environment, requiring only standard microbiological practices.

BSL-1 minimal-hazard classification

DOI-backed graph linking the absence of significant pathogen hazard properties to BSL-1 classification and minimal containment requirements.

BSL-1 minimal-hazard classification Interactive directed graph showing evidence-backed causal relationships for biosafety level 1.

Edge evidence

  • low pathogen hazard produces biosafety level 1 METPO:2000202

    Low pathogen hazard yields BSL-1 classification.

    • DOI:10.1146/annurev.micro.62.081307.162938 virulence factors Supports the absence of virulence factors as the basis of BSL-1 classification.
  • biosafety level 1 is a biosafety level rdfs:subClassOf

    BSL-1 is a quantitative class within the biosafety-level classification axis.

    • DOI:10.1146/annurev.micro.62.081307.162938 virulence factors Supports BSL-1 as a member of the biosafety-level classification.
  • low-risk agent qualifies for biosafety level 1

    Low-risk agents unlikely to cause disease in healthy adults qualify for BSL-1.

    • DOI:10.3390/laboratories1030013 BSL-1 is the level for low-risk agents unlikely to cause disease in healthy adults.
  • low pathogen hazard qualifies for biosafety level 1

    Organisms not known to consistently cause disease in healthy adults qualify for BSL-1.

    • DOI:10.2172/1887109 Defined strains of viable microorganisms not known to consistently cause disease in healthy adult humans.
  • standard microbiological practices enables containment at biosafety level 1

    Standard microbiological practices provide the basic containment defining BSL-1.

    • DOI:10.47328/ufvbbt.2024.220 BSL-1 represents a basic level of containment relying on standard microbiological best practices and procedures.
  • hand washing is good microbiological practice supporting standard microbiological practices

    Hand washing is among the best good microbiological practices underpinning standard practices.

    • DOI:10.3389/fpubh.2022.965853 Among GMPP, one of the best practices is hand washing.
  • biosafety risk assessment factors determine biosafety level selection

    Risk assessment factors determine the biosafety level assigned to work.

    • DOI:10.2172/1887109 Pathogenicity, route of transmission, stability, infectious dose, concentration, origin, prophylaxis, and personnel experience determine biosafety level.
  • biosafety level selection assigns biosafety level

    The selection process assigns a biosafety level on the classification axis.

    • DOI:10.2172/1887109 Risk assessment factors determine risk and therefore biosafety level assignment.
  • specific virulence traits enables disease causation RO:0002327

    Specific virulence traits render an organism capable of causing disease; their absence is compatible with BSL-1.

    • DOI:10.3390/microorganisms11020344 Strains encode specific virulence traits that render them capable of causing disease.

Provenance

Source
METPO (2025-11-25)
Author
Anthea Guo
Definition source
DOI:10.1146/annurev.micro.62.081307.162938

Parent traits (1)

Synonyms (1)

  • 1 RELATED_SYNONYM · metpo.owl

kg-microbe context

Matched 1 kg-microbe node via direct_metpo.

  • METPO:1001102 [+13.390, -49.149, -21.083, +19.067, …]

512-dim DeepWalkSkipGramEnsmallen embedding from kg-microbe (2026-04-25).

Nearest neighbors in embedding space

Top-8 cosine-similar METPO traits from the 2026-04-25 deepwalk (512-D).

Curation history

  1. · SEEDED_FROM_METPO · seed_from_metpo

    imported from data/raw/metpo.owl (CLASS)

  2. · CURATED_CAUSAL_GRAPH · claude

    Added DOI-backed causal graph linking low pathogen hazard to BSL-1 classification.

  3. · GROUND_CAUSAL_PREDICATES · claude

    Grounded 2 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (METPO:2000202×1, rdfs:subClassOf×1).

  4. · ENRICH_CAUSAL_GRAPH · claude

    Added 7 evidence-backed generic edges (7 new nodes) from the deep-research report.

  5. · GROUND_CAUSAL_PREDICATES · claude

    Grounded 1 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (RO:0002327×1).