pH optimum high

Edge evidence

• alkaline external pH selects for alkaliphile cytoplasmic pH homeostasis METPO:2007401

  Alkaline environments select for alkaliphile cytoplasmic pH homeostasis.

  • DOI:10.1038/nrmicro2549 alkaliphiles Supports the alkaliphile regime as the environmental context for high-pH optima.
• Na+/H+ antiporters regulates alkaliphile cytoplasmic pH homeostasis RO:0002211

  Na+/H+ antiporters drive proton re-import that acidifies the cytoplasm relative to the alkaline external pH.

  • DOI:10.1016/j.tim.2007.02.005 proton motive force Supports antiporter-driven proton re-import as the alkaliphile mechanism for maintaining the proton motive force.
• alkaliphile cytoplasmic pH homeostasis produces pH optimum high METPO:2000202

  Alkaliphile pH homeostasis yields an alkaline pH-optimum setpoint.

  • DOI:10.1038/nrmicro2549 alkaliphiles Supports a high-pH optimum as the alkaliphile / extreme-alkaliphile outcome.
• pH optimum high is a pH optimum rdfs:subClassOf

  pH optimum high is a quantitative bin of the pH-optimum phenotype.

  • DOI:10.1038/nrmicro2549 cytoplasmic pH Supports an alkaline optimum as a value within the pH-optimum distribution.
• CPA/Nha family Na+/H+ antiporters decreases intracellular Na+ concentration RO:0002212

  CPA/Nha family Na+/H+ antiporters export Na+, lowering intracellular Na+ as part of pH homeostasis.

  • DOI:10.1128/AEM.00145-24 Monovalent cation/proton antiporters import H+ and efflux Na+; Na+/H+ antiporters effectively decrease the intracellular Na+ concentration.
• TrkAH K+ uptake system maintains alkaliphile cytoplasmic pH homeostasis

  TrkAH K+ uptake supports membrane potential adjustment and cytoplasmic pH homeostasis.

  • DOI:10.1128/AEM.00145-24 TrkAH transport system takes up K+ and maintains pH homeostasis, adjusting membrane potential.
• Rnf complex generates transmembrane Na+ gradient biolink:produces

  Rnf complex expels sodium ions to establish a transmembrane Na+ gradient usable for bioenergetics at high pH.

  • DOI:10.1515/hsz-2015-0137 Rnf transfers electrons from reduced ferredoxin to NAD and uses the redox difference to expel sodium, establishing a transmembrane sodium gradient.
• branched respiratory chain terminal oxidases produces proton motive force METPO:2000202

  Branched respiratory chain terminal oxidases pump protons (with varying efficiencies) to sustain proton motive force at high pH.

  • DOI:10.3389/fmicb.2024.1468929 Cyt. aa3 pumps protons at 0.7 H+/electron; ba3 and bb3 pump at 0.5 H+/electron, supporting usable PMF at high pH.
• acidic plasma membrane polymers enhances proton motive force

  Acidic plasma-membrane polymers aid proton retention and enhance proton motive force generation at high external pH.

  • DOI:10.3390/min14090861 Alkaliphilic Bacillus enhances proton motive force generation by synthesis of acidic plasma membrane (teichuronopeptide, peptidoglycan, teichuronic acid).
• organic acid secretion regulates pH balance RO:0002211

  Secretion of organic acids by alkaliphiles permits cytoplasmic pH balance against alkaline stress.

  • DOI:10.3390/min14090861 Secretion of organic acids by alkaliphilic microbes is a crucial metabolic activity that permits pH balance.