temperature range mid1

Edge evidence

• lower-mesophile adaptation enables temperature range mid1 RO:0002327

  Lower-mesophile adaptation enables growth across 22–27 °C.

  • DOI:10.1146/annurev-micro-091313-103612 more unsaturated fatty acids Supports homoviscous mesophile adaptation as the lower-mesophile range mechanism.
• temperature range mid1 is a temperature range rdfs:subClassOf

  Temperature range mid1 is a quantitative bin of the temperature-range phenotype.

  • DOI:10.1016/s0300-9629(97)00003-0 adapted to environments of high temperature Supports the 22–27 °C range as a value within the temperature-range distribution.
• temperature decrease causes membrane rigidification/thickening biolink:causes

  Cooling reduces membrane fluidity and increases bilayer thickness, the initiating physical signal for adaptation.

  • DOI:10.1007/s42770-023-01057-4 Membrane rigidification and increased thickness act as the primary physical signal upon cooling.
• fatty-acid desaturation increases membrane fluidity RO:0002213

  Double bonds disrupt tight acyl-chain packing, reversing cold-induced rigidification.

  • DOI:10.1128/spectrum.03925-23 Desaturation fluidizes the membrane and reduces thickness; strong and broadly conserved principle.
• anteiso-branched fatty acids increases membrane fluidity RO:0002213

  Anteiso chains disorder lipids effectively, supporting growth at lower temperatures.

  • DOI:10.3390/cells12101353 Anteiso-BCFAs are more effective at fluidizing membranes than iso-BCFAs; generalizable across many Gram-positives.
• branched-chain amino acids precursor for anteiso-branched fatty acids

  Branched-chain amino acids supply carbon skeletons for iso/anteiso-branched fatty acid synthesis.

  • DOI:10.1007/s42770-023-01057-4 Iso- and anteiso-branched FAs are derived from valine, leucine, and isoleucine precursors.
• RNA thermometer melting exposes Shine-Dalgarno sequence exposure

  Temperature-dependent melting of RNA thermometers exposes the Shine-Dalgarno sequence to control translation.

  • DOI:10.1007/s12275-023-00031-x 5'-UTR cis-elements occlude or expose Shine-Dalgarno sequences to control translation; strong general mechanism.
• temperature shift changes DNA supercoiling

  DNA topology functions as a thermosensor that globally reprograms transcription after temperature change.

  • DOI:10.1007/s12275-023-00031-x DNA topology acts as a thermosensor; cold stress enhances negative DNA supercoiling.