temperature range mid2

Edge evidence

• baseline mesophile adaptation enables temperature range mid2 RO:0002327

  Baseline mesophile adaptation enables growth across 27–30 °C.

  • DOI:10.1146/annurev-micro-091313-103612 more unsaturated fatty acids Supports baseline mesophile homeoviscous adaptation as the range mechanism.
• temperature range mid2 is a temperature range rdfs:subClassOf

  Temperature range mid2 is a quantitative bin of the temperature-range phenotype.

  • DOI:10.1016/s0300-9629(97)00003-0 adapted to environments of high temperature Supports the 27–30 °C range as a value within the temperature-range distribution.
• homeoviscous adaptation maintains membrane fluidity

  Homeoviscous adaptation maintains membrane lipid viscosity/fluidity.

  • DOI:10.1007/s42770-023-01057-4 Homeoviscous adaptation regulates membrane lipid viscosity; generic background mechanism for mesophilic temperature tolerance.
• unsaturated fatty acid fraction increases membrane fluidity RO:0002213

  Increased unsaturated fatty acid fraction increases membrane fluidity.

  • DOI:10.1007/s12275-023-00031-x Higher unsaturated content increases fluidity; canonical general bacterial thermoadaptation mechanism.
• hopanoids / sterol-like molecules regulates membrane fluidity RO:0002211

  Hopanoids / sterol-like molecules regulate membrane fluidity.

  • DOI:10.1007/s42770-023-01057-4 Hopanoids and sterol-like molecules act as regulators of membrane fluidity; broad membrane-modulator edge.
• membrane fluidity enables temperature range mid2 RO:0002327

  Maintained membrane fluidity enables growth across the mid2 temperature range.

  • DOI:10.1146/annurev-micro-091313-103612 Functional membrane fluidity underlies homeoviscous adaptation supporting the mesophile range.
• elevated temperature opens RNA thermometer 5′-UTR structure

  Elevated temperature melts/opens RNA thermometer 5′-UTR secondary structure.

  • DOI:10.1007/s12551-025-01290-1 5′-UTR secondary structures melt upon heat exposure, exposing ribosome binding sites; broad review-level support.
• temperature shift / heat shock induces heat-shock proteins / chaperones

  Temperature shift / heat shock induces heat-shock proteins and chaperones.

  • DOI:10.1007/s12275-023-00031-x Temperature shifts induce heat- and cold-shock proteins; high-confidence general stress-response edge.
• heat-shock proteins / chaperones counteracts protein denaturation / aggregation

  Heat-shock proteins / chaperones counteract protein denaturation and aggregation.

  • DOI:10.1007/s12275-023-00031-x Chaperones counteract denaturation and aid tolerance; strong general proteostasis edge.
• baseline mesophile adaptation characterizes mesophilic organisms

  Mesophilic organisms grow between ~20 °C and ~45 °C, bracketing the mid2 range.

  • DOI:10.1007/s42770-023-01057-4 Mesophiles grow between room temperature (~20 °C) and ~45 °C; scope-defining edge placing 27-30 °C within mesophily.