Eleos system

traitmech:000250 · CLASS · PROPOSED

A phage defense system in which an organism possesses an Eleos locus represented by LeoA, LeoB, LeoBC, and LeoC profiles that can protect bacteria from bacteriophage infection.

Trait evidence (9)

DOI:10.1016/j.chom.2022.09.017
discovery of 21 defense systems that protect bacteria from phages, based on computational genomic analyses and phage-infection experiments

Millman et al. report the computational and experimental cohort that DefenseFinder cites for Eleos as a bacterial anti-phage system.
DOI:10.1101/2022.05.11.491447
discovery of 21 new defense systems that protect bacteria from phages, based on computational genomic analyses and phage infection experiments

The bioRxiv version of Millman et al. independently carries the 21-system discovery claim linked from DefenseFinder's Eleos article registry.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md
Eleos | 10\.1101/2022\.05\.11\.491447 | An expanding arsenal of immune systems that protect bacteria from phages

The DefenseFinder model registry maps the named Eleos system to the Millman et al. antiphage-system discovery preprint.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv
Eleos Eleos 2 2 Eleos__LeoA, Eleos__LeoB, Eleos__LeoBC, Eleos__LeoC

The DefenseFinder rules table models Eleos as a two-gene system over LeoA, LeoB, LeoBC, and LeoC mandatory-profile choices.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md
Eleos__LeoA | Eleos__LeoA | Eleos

The DefenseFinder HMM inventory records LeoA as an Eleos profile.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md
Eleos__LeoA2 | Eleos__LeoA2 | Eleos

The DefenseFinder HMM inventory records an additional LeoA profile for Eleos.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md
Eleos__LeoB | Eleos__LeoB | Eleos

The DefenseFinder HMM inventory records LeoB as an Eleos profile.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md
Eleos__LeoBC | Eleos__LeoBC | Eleos

The DefenseFinder HMM inventory records LeoBC as an Eleos profile.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md
Eleos__LeoC | Eleos__LeoC | Eleos

The DefenseFinder HMM inventory records LeoC as an Eleos profile.

Eleos loci confer bacterial phage defense

Conservative system-level sketch linking possession of an Eleos locus to restricted bacteriophage propagation without asserting the unresolved phage trigger or molecular output.

NONMECHANISTIC · The graph captures Eleos as a named anti-phage system with DefenseFinder LeoA, LeoB, LeoBC, and LeoC profiles while leaving its phage trigger, molecular substrate, antiviral effector output, and subtype breadth unresolved.

Edge evidence

Eleos locus contributes to restricted phage propagation RO:0002326
DefenseFinder maps Eleos to a bacterial anti-phage-system discovery preprint and represents Eleos loci through LeoA, LeoB, LeoBC, and LeoC component profiles.
- DOI:10.1016/j.chom.2022.09.017 discovery of 21 defense systems that protect bacteria from phages Millman et al. describe the anti-phage discovery cohort that the DefenseFinder Eleos registry row maps to the Eleos system.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md Eleos | 10\.1101/2022\.05\.11\.491447 | An expanding arsenal of immune systems that protect bacteria from phages The DefenseFinder registry maps Eleos itself to the Millman et al. bacterial antiphage-system discovery preprint.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv Eleos Eleos 2 2 Eleos__LeoA, Eleos__LeoB, Eleos__LeoBC, Eleos__LeoC The DefenseFinder rules table supports LeoA, LeoB, LeoBC, and LeoC as Eleos system profile choices.
restricted phage propagation confers Eleos system METPO:2007700
Eleos-mediated phage restriction realizes the Eleos system trait.
- DOI:10.1016/j.chom.2022.09.017 discovery of 21 defense systems that protect bacteria from phages Millman et al. place the Eleos discovery cohort in the set of bacterial systems that protect against phages.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md Eleos | 10\.1101/2022\.05\.11\.491447 | An expanding arsenal of immune systems that protect bacteria from phages DefenseFinder records Eleos as a named system from the Millman et al. antiphage discovery preprint.
Eleos system is a phage defense system rdfs:subClassOf
Eleos system possession is a phage-defense-system trait.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md An expanding arsenal of immune systems that protect bacteria from phages DefenseFinder associates Eleos with the Millman et al. bacterial antiphage-system discovery paper.

Provenance

Identifier source: TraitMech local identifier
Definition source: DOI:10.1016/j.chom.2022.09.017

Parent traits (1)

phage defense system traitmech:000209

Synonyms (1)

Eleos EXACT_SYNONYM · https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md

kg-microbe context

No kg-microbe node embedding matched this record in the 2026-04-25 deepwalk.

Discussions and Knowledge Gaps (1)

Open questions attached to this trait. Seeded by just knowledge-gap-scan and curated; see the corpus-wide index.

Resolve Eleos phage triggers and effector outputs before minting narrower Eleos mechanism children.

KNOWLEDGE GAP OPEN eleos-mechanism-gap · raised by codex · 2026-09-18

Attached to causal_graphs#eleos_locus_restricts_phage

Millman et al. and DefenseFinder support Eleos as a named anti-phage system with LeoA, LeoB, LeoBC, and LeoC profiles, but the trigger, molecular substrate, antiviral effector output, and subtype-specific mechanism are not resolved enough here to assert a narrower mechanistic child trait.

Curation history

2026-09-18T20:38:41Z · MINTED_TRAITMECH_ID · codex
Minted Eleos system as a DOI-backed GENOMICS TraitRecord under phage defense system after an ignored-and-hidden duplicate review found no exact live TraitMech, METPO, or prior proposal record; the replacement placeholder is reserved in proposals/metpo_traitmech_v127.