FS-HEPN-TM system

traitmech:000347 · CLASS · PROPOSED

A phage defense system in which an organism possesses an FS_HEPN_TM locus represented by DefenseFinder as a two-profile model requiring FS_HEPN_TM__HEPN and FS_HEPN_TM__TM.

Trait evidence (6)

PMID:35985290
the phage-inducible chromosomal islands (PICIs), carry an impressive arsenal of defense mechanisms

Fillol-Salom et al. support phage-inducible chromosomal islands as carriers of mobile-element defense mechanisms.
PMID:35985290
These defense systems provide broad immunity, blocking not only phage reproduction, but also plasmid and non-cognate PICI transfer.

Fillol-Salom et al. support PICI-encoded defense systems as broad immunity determinants against phage reproduction and other mobile genetic element transfer.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md
FS_HEPN_TM | 10\.1016/j\.cell\.2022\.07\.014 | Bacteriophages benefit from mobilizing pathogenicity islands encoding immune systems against competitors

The DefenseFinder article registry maps the named FS_HEPN_TM system to the Fillol-Salom et al. PICI defense-system paper.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv
FS_HEPN_TM FS_HEPN_TM 2 2 FS_HEPN_TM__HEPN, FS_HEPN_TM__TM

The DefenseFinder rules table models FS_HEPN_TM as a two-profile system requiring the FS_HEPN_TM__HEPN and FS_HEPN_TM__TM profiles.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md
| FS_HEPN_TM__HEPN | FS_HEPN_TM__HEPN | FS_HEPN_TM | PF05168.15 | 20 |

The DefenseFinder HMM inventory records FS_HEPN_TM__HEPN under FS_HEPN_TM.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md
| FS_HEPN_TM__TM | FS_HEPN_TM__TM | FS_HEPN_TM | Custom | 20 |

The DefenseFinder HMM inventory records FS_HEPN_TM__TM under FS_HEPN_TM.

FS-HEPN-TM loci confer bacterial phage defense

Conservative system-level sketch linking possession of an FS_HEPN_TM locus to broad mobile-element defense without asserting the unresolved phage trigger or molecular output.

NONMECHANISTIC · The graph captures FS-HEPN-TM as a named DefenseFinder two-profile system in the Fillol-Salom PICI defense family while leaving its natural host breadth, helper-phage trigger, HEPN-family substrate, and transmembrane partner function unresolved.

Edge evidence

FS_HEPN_TM locus contributes to PICI-encoded mobile-element defense RO:0002326
DefenseFinder maps FS_HEPN_TM to the Fillol-Salom et al. PICI-encoded immunity study and models it as a two-profile system requiring HEPN-family and transmembrane profiles.
- PMID:35985290 the phage-inducible chromosomal islands (PICIs), carry an impressive arsenal of defense mechanisms Fillol-Salom et al. support PICI loci as carriers of phage and mobile-element defense mechanisms.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md FS_HEPN_TM | 10\.1016/j\.cell\.2022\.07\.014 | Bacteriophages benefit from mobilizing pathogenicity islands encoding immune systems against competitors The DefenseFinder article registry maps the named FS_HEPN_TM system to the Fillol-Salom et al. PICI defense-system paper.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv FS_HEPN_TM FS_HEPN_TM 2 2 FS_HEPN_TM__HEPN, FS_HEPN_TM__TM The DefenseFinder rules table models FS_HEPN_TM as a two-profile system requiring the FS_HEPN_TM__HEPN and FS_HEPN_TM__TM profiles.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md | FS_HEPN_TM__HEPN | FS_HEPN_TM__HEPN | FS_HEPN_TM | PF05168.15 | 20 | The DefenseFinder HMM inventory records FS_HEPN_TM__HEPN under FS_HEPN_TM.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md | FS_HEPN_TM__TM | FS_HEPN_TM__TM | FS_HEPN_TM | Custom | 20 | The DefenseFinder HMM inventory records FS_HEPN_TM__TM under FS_HEPN_TM.
PICI-encoded mobile-element defense confers FS-HEPN-TM system METPO:2007700
FS_HEPN_TM-associated mobile-element defense realizes the FS-HEPN-TM system trait.
- PMID:35985290 These defense systems provide broad immunity, blocking not only phage reproduction, but also plasmid and non-cognate PICI transfer. Fillol-Salom et al. support PICI-encoded defense systems as broad mobile-element immunity determinants.
FS-HEPN-TM system is a phage defense system rdfs:subClassOf
FS-HEPN-TM system possession is a phage-defense-system trait.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md FS_HEPN_TM | 10\.1016/j\.cell\.2022\.07\.014 | Bacteriophages benefit from mobilizing pathogenicity islands encoding immune systems against competitors The DefenseFinder article registry maps the named FS_HEPN_TM system to the Fillol-Salom et al. PICI defense-system paper.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv FS_HEPN_TM FS_HEPN_TM 2 2 FS_HEPN_TM__HEPN, FS_HEPN_TM__TM The DefenseFinder rules table models FS_HEPN_TM as a two-profile system requiring the FS_HEPN_TM__HEPN and FS_HEPN_TM__TM profiles.

Provenance

Identifier source: TraitMech local identifier
Definition source: DOI:10.1016/j.cell.2022.07.014

Parent traits (1)

phage defense system traitmech:000209

Synonyms (3)

FS_HEPN_TM RELATED_SYNONYM · https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md
FS_HEPN_TM__HEPN RELATED_SYNONYM · https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md
FS_HEPN_TM__TM RELATED_SYNONYM · https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md

kg-microbe context

No kg-microbe node embedding matched this record in the 2026-04-25 deepwalk.

Discussions and Knowledge Gaps (1)

Open questions attached to this trait. Seeded by just knowledge-gap-scan and curated; see the corpus-wide index.

Resolve FS_HEPN_TM natural hosts, helper-phage triggers, HEPN-family substrates, and transmembrane partner activity before minting narrower FS_HEPN_TM mechanism children.

KNOWLEDGE GAP OPEN fs-hepn-tm-mechanism-gap · raised by codex · 2026-09-21

Attached to causal_graphs#fs_hepn_tm_locus_restricts_phage

Fillol-Salom et al. support phage-inducible chromosomal islands as carriers of defense systems that provide broad immunity, and DefenseFinder models FS_HEPN_TM as a two-profile HEPN/transmembrane system. Its exact natural host breadth, helper-phage trigger, substrate, and profile-to-activity mapping remain unresolved.

Curation history

2026-09-21T22:22:47Z · MINTED_TRAITMECH_ID · codex
Minted FS-HEPN-TM system as a DOI-backed GENOMICS TraitRecord under phage defense system after an ignored-and-hidden duplicate review found no exact live TraitMech, METPO, history, or prior proposal record; the replacement placeholder is reserved in proposals/metpo_traitmech_v224.