GC low

Edge evidence

• moderate mutation bias produces GC low METPO:2000202

  Moderate mutation-bias balance yields mid-range GC composition.

  • DOI:10.1186/1471-2148-10-374 mutation bias Supports mutation-bias balance as the basis of mid-range GC bins.
• GC low is a GC content rdfs:subClassOf

  GC low is a quantitative bin of the GC-content phenotype.

  • DOI:10.1038/nrg2358 GC content Supports the 42.65–57.0% bin as a value within the GC-content distribution.
• DNA repair defect causes mutational spectrum biolink:causes

  Defects in DNA repair genes (MMR, BER, HR) create distinctive bacterial mutational signatures.

  • DOI:10.1038/s41467-023-42916-w Defects in DNA repair create distinctive mutational signatures attributable to MMR, BER, or HR genes.
• cytosine deamination / C>T bias shifts toward AT-enriching mutation spectrum

  Cytosine deamination / C>T transition bias shifts the spectrum toward AT-enriching substitutions.

  • DOI:10.1038/s41467-023-42916-w C>T was the most common mutation type in 69 of 84 SBS spectra, potentially due to cytosine deamination.
• AT-enriching mutation spectrum associated with GC low biolink:associated_with

  A spectrum enriched for C>A/T and depleted for C>G is associated with lower genomic G+C content.

  • DOI:10.1038/s41467-023-42916-w Genomic G+C content negatively correlates with C>A/T proportion and positively with C>G mutations.
• DNA replication/repair enzyme bias shapes GC content

  Biases of DNA replication/repair enzymes and inter-nucleotide mutation rates shape genomic GC percent.

  • DOI:10.3389/fmicb.2024.1412318 Genome GC% depends in part on mutation rates between nucleotides; replication/repair enzymes present biases.