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fumarate respiration

traitmech:000196 · CLASS · PROPOSED

An anaerobic respiration in which an organism uses fumarate as the terminal electron acceptor and reduces it to succinate for energy conservation.

Trait evidence (3)

  • DOI:10.1128/mBio.03238-19
    under anaerobic conditions, fumarate can serve as a terminal electron acceptor, with fumarate reductase (FRD) transferring electrons from the reduced quinone, producing succinate

    Ito et al. summarize Bacteroides anaerobic respiration as quinone-linked transfer to fumarate through fumarate reductase, producing succinate.

  • DOI:10.1128/JB.00389-22
    The respiratory chain responsible for anaerobic respiration (NADH to fumarate) involves two NADH dehydrogenases

    Butler et al. describe the B. fragilis anaerobic respiratory chain as an NADH-to-fumarate route.

  • DOI:10.1128/JB.00389-22
    Analysis of fumarate reductase showed that it is synthesized and active under anaerobic and nanaerobic conditions

    The 2023 biochemical assay shows fumarate reductase remains synthesized and active in B. fragilis membranes under strictly anaerobic growth and under low-oxygen growth.

Provenance

Identifier source
TraitMech local identifier
Definition source
DOI:10.1128/mBio.03238-19

Parent traits (1)

Synonyms (1)

  • anaerobic respiration on fumarate RELATED_SYNONYM · DOI:10.1128/JB.00389-22

kg-microbe context

No kg-microbe node embedding matched this record in the 2026-04-25 deepwalk.

Canonical examples (1)

Organisms cited as exemplars of this trait. Taxon ids are NCBITaxon and link out to the NCBI record.

Discussions and Knowledge Gaps (1)

Open questions attached to this trait. Seeded by just knowledge-gap-scan and curated; see the corpus-wide index.

Resolve an exact external ontology class for organism-level fumarate respiration before adding a TraitRecord xref.

CURATION TODO OPEN fumarate-respiration-xref-gap · raised by codex · 2026-09-15

Not yet attached to a section of this record — a curator sets attaches_to (e.g. causal_graphs#some_edge) so the gap shows beside the mechanism it concerns.

The pinned METPO snapshot contains only obsolete Fumarate respiration and no active organism-level class for anaerobic respiration using fumarate as the terminal electron acceptor. Potential GO, Rhea, EC, and protein-family terms for fumarate reductase or the fumarate-to-succinate reaction are narrower than the whole-organism anaerobic respiration phenotype and should be checked separately before grounding FrdABCD-level causal nodes.

Curation history

  1. · MINTED_TRAITMECH_ID · codex

    Minted fumarate respiration as a DOI-backed anaerobic respiration TraitRecord after a repository-wide duplicate review covering ignored and hidden files; the local METPO snapshot has only obsolete Fumarate respiration and the replacement placeholder is reserved in proposals/metpo_traitmech_v73.