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memory of acquired stress resistance

traitmech:000712 · CLASS · PROPOSED

A physiological phenotype in which a microbial cell or lineage retains elevated resistance to a later stress challenge after a previous inducing stress has been removed, through persistence of a non-genetic state.

Trait evidence (2)

  • DOI:10.1534/genetics.112.143016
    resistance persisted for four to five generations after cells were removed from the prior salt treatment

    Guan et al. 2012, PMID:22851651, PMC3454879; scientific abstract, directly matched in publisher HTML and source-qualified MED. The resistance endpoint is H2O2 survival, not faster transcriptional reactivation. Relevant Methods, Results and actual Figure 1 and S1/S2 were inspected. BY4741-background cells received 0.7 M NaCl for 60 minutes, then grew in fresh stress-free YPD. Figure 1 describes three-to-four doublings over 360 minutes; four-to-five generations is the abstract statement. Methods specifies 11 peroxide doses plus control, whereas Figure 1A captions ten plotted doses. The normalized survival score is not a fraction of memory-bearing cells. S1 growth-arrest interventions and S2 engineered UCC8613 daughter marking are separate contexts. No natural canonical exemplar is asserted. The publisher's formula rendering differs from MED H(2)O(2); the selected span matches both without changing either source. Raw data were not independently reanalyzed.

  • DOI:10.1371/journal.pbio.2003853
    the cells inheriting this ancestral PA displayed a significantly increased heat resistance compared to their isogenic, PA-free siblings.

    Govers et al. 2018, PMID:30153247, PMC6112618; scientific abstract, not Author Summary, matched in primary XML and source-qualified MED. Relevant Results and Methods, actual Figure 4 and S6 were inspected. Engineered MG1655 IbpA-msfGFP reporters received 47 C for 15 minutes, recovered with growth, then faced 51 C for 7 minutes. Figure 4D compares aggregate-bearing and aggregate-free descendants; Figure 4C detects no improved population-average survival after pretreatment. Survival requires growth and division within eight hours. S6 detects no age-bin survival difference in this assay, not universal age independence. Reporter-induced clustering was separately tested in actual Figure 1, previously inspected for traitmech:000711; a monomeric label alone is not proof against artifacts. Synthetic induction experiments and their duration are not transferred to these heat-induced lineages. Raw data and all other memory-related figure images were not independently assessed.

Provenance

Identifier source
TraitMech local identifier
Definition source
DOI:10.1534/genetics.112.143016

Parent traits (1)

kg-microbe context

No kg-microbe node embedding matched this record in the 2026-04-25 deepwalk.

Discussions and Knowledge Gaps (3)

Open questions attached to this trait. Seeded by just knowledge-gap-scan and curated; see the corpus-wide index.

Preserve persistence after stress removal and the resistance endpoint.

CURATION TODO OPEN stress-resistance-memory-scope-and-hierarchy · raised by codex · 2026-10-12

Not yet attached to a section of this record — a curator sets attaches_to (e.g. causal_graphs#some_edge) so the gap shows beside the mechanism it concerns.

Compare matched genetic backgrounds and challenge conditions after removal of the inducing stress. Persistent resistance is not merely faster transcriptional reactivation or faster reacquisition after a second induction. A marker, aggregate, gene, ongoing stress response or single survival measurement alone does not establish this history-dependent phenotype. Cell-level or lineage-restricted protection need not improve population-average survival. No fixed duration, number of divisions, stressor identity or molecular mechanism is required. Genetic adaptation, carbon-source memory, cue-triggered anticipation, diversifying bet hedging, persister formation and unequal aggregate inheritance are not equivalent, though particular observations can overlap. Unqualified cellular memory, stress priming and cross-protection are not asserted as exact synonyms. Stress response (traitmech:000078) concerns sensing and mounting protection; its research report includes cross-protection as an output but does not establish persistence after removal. METPO:1000059 phenotype is the conservative parent pending hierarchy review; existing records are unchanged.

Resolve natural strain provenance and assay-specific mechanisms before extending this draft.

KNOWLEDGE GAP OPEN stress-resistance-memory-evidence-limits · raised by codex · 2026-10-12

Not yet attached to a section of this record — a curator sets attaches_to (e.g. causal_graphs#some_edge) so the gap shows beside the mechanism it concerns.

Neither a uniform species-wide phenotype nor a shared molecular mechanism is established. Laboratory backgrounds and engineered reporters remain qualified evidence, not natural canonical taxa. No causal graph, exact synonym or external equivalence is asserted. MED/Crossref and visible publisher notice checks on 2026-10-12 exposed no linked correction or retraction for the retained sources; this bounded check does not prove notice absence. Guan's Crossref has-review relation is not a correction or independent experiment. The publisher HTML was directly retrieved through its public redirect after other endpoints failed. Source access limits and section-specific assay descriptions are retained rather than silently harmonized.

Retain historical stress-response neighbors without reactivating their identifiers.

CURATION TODO OPEN stress-resistance-memory-metpo-identity · raised by codex · 2026-10-12

Not yet attached to a section of this record — a curator sets attaches_to (e.g. causal_graphs#some_edge) so the gap shows beside the mechanism it concerns.

Pinned and current released METPO contain METPO:1000293 obsolete stress response and METPO:1000222 obsolete oxidative stress response, marked deprecated below ObsoleteClass with an OMO:0001000 reason annotation and no replacement or consider annotation in the inspected releases. These broader lexical neighbors do not define persistence after stress removal. Their historical rationale remains unresolved; neither is reactivated or used as an exact xref. Ignored/hidden available-file searches, retained historical trees, normalized trait semantics, pending PRs and ontology RDF found no exact memory class in the inspected scope. The pinned ontology is unchanged; this is not discovery exhaustion or a sequence-feature trait.

Curation history

  1. · MINTED_TRAITMECH_ID · codex

    Added memory of acquired stress resistance with two primary DOI references and directly checked snippets. Retained post-removal, resistance-endpoint, cell-versus-population and source-context limits. Reserved 000712, v588 and 1066500-1066599 after ignored/hidden, historical-tree, independent-copy and pending-PR checks. Examples and mechanism graph deferred; existing records unchanged. Timestamp is the observed UTC curation decision.

Recorded curation sessions

  • · codex
    • CREATE — Add memory of acquired stress resistance with primary evidence

      Added a PROPOSED physiological class with Guan 2012 DOI:10.1534/genetics.112.143016 and Govers 2018 DOI:10.1371/journal.pbio.2003853, directly checked scientific-abstract snippets, inspected endpoint-specific figures, and explicit post-removal, transcription-versus-survival, cell-versus-population and reporter qualifications. Reserved traitmech:000712, v588 and 1066500-1066599 after ignored/hidden current-file, retained historical-tree, known independent-copy and pending-PR checks. Natural canonical taxa, exact external mappings and a shared causal mechanism are deferred. Existing TraitRecords and the pinned ontology are unchanged. Validation and adversarial review outcomes are recorded separately rather than claimed in advance.

    Read this curation session