TraitMech

TraitMech › PHYSIOLOGY

alanine arylamidase activity

traitmech:000161 · CLASS · PROPOSED

A physiological enzyme-activity phenotype in which a cell exhibits alanine arylamidase/alanyl aminopeptidase activity, releasing N-terminal residues from peptide, amide, or arylamide substrates with preference for alanine.

Trait evidence (2)

  • https://iubmb.qmul.ac.uk/enzyme/EC3/4/11/2.html
    <b>Reaction:</b> Release of an N-terminal amino acid, Xaa<img src="../../../EZgif/FISS.GIF" align=top>Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action).

    The NC-IUBMB EC 3.4.11.2 entry accepts membrane alanyl aminopeptidase and places the scissile-bond FISS.GIF image between Xaa and Yaa in a reaction line that includes arylamide substrates and preferential N-terminal alanine.

  • DOI:10.1099/ijsem.0.006017
    enzymatic activities are present for: α-galactosidase, N-acetyl-β-glucosaminidase, arginine arylamidase, proline arylamidase, leucyl glycine arylamidase, phenylalanine arylamidase, leucine arylamidase, tyrosine arylamidase, alanine arylamidase, glycine arylamidase, histidine arylamidase, glutamyl glutamic acid arylamidase, serine arylamidase, valine arylamidase, cysteine arylamidase, esterase, esterase lipase, alpha-chymotrypsin

    Srinivasan et al. listed alanine arylamidase among enzymatic activities present in the Amygdalobacter indicium species description, supporting the API arylamidase row as a bacterial enzyme-activity phenotype.

Provenance

Identifier source
TraitMech local identifier
Definition source
https://iubmb.qmul.ac.uk/enzyme/EC3/4/11/2.html

Parent traits (1)

Synonyms (3)

  • alanyl aminopeptidase RELATED_SYNONYM · https://iubmb.qmul.ac.uk/enzyme/EC3/4/11/2.html
  • alanine aminopeptidase RELATED_SYNONYM · https://iubmb.qmul.ac.uk/enzyme/EC3/4/11/2.html
  • L-alanine aminopeptidase RELATED_SYNONYM · https://iubmb.qmul.ac.uk/enzyme/EC3/4/11/2.html

kg-microbe context

No kg-microbe node embedding matched this record in the 2026-04-25 deepwalk.

Canonical examples (1)

Organisms cited as exemplars of this trait. Taxon ids are NCBITaxon and link out to the NCBI record.

Discussions and Knowledge Gaps (1)

Open questions attached to this trait. Seeded by just knowledge-gap-scan and curated; see the corpus-wide index.

Resolve an exact external ontology class for alanine arylamidase activity before adding a TraitRecord xref.

CURATION TODO OPEN alanine-arylamidase-activity-xref-gap · raised by codex · 2026-09-12

Not yet attached to a section of this record — a curator sets attaches_to (e.g. causal_graphs#some_edge) so the gap shows beside the mechanism it concerns.

GO:0016285 alanyl aminopeptidase activity denotes the catalytic molecular function rather than the organism-level alanine arylamidase/alanyl aminopeptidase phenotype, so it is appropriate as a causal-node grounding for that enzyme activity and not as an equivalent TraitRecord xref.

Curation history

  1. · MINTED_TRAITMECH_ID · codex

    Minted alanine arylamidase activity as a URL/DOI-backed TraitRecord after a repository-wide duplicate review covering ignored and hidden files; METPO has no exact alanine arylamidase activity class yet.