alpha-mannosidase activity

traitmech:000150 · CLASS · PROPOSED

A physiological enzyme-activity phenotype in which a cell produces active alpha-mannosidase enzymes that hydrolyze terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.

Trait evidence (2)

https://iubmb.qmul.ac.uk/enzyme/EC3/2/1/24.html
Reaction: Hydrolysis of terminal, non-reducing α-D-mannose residues in α-D-mannosides

The NC-IUBMB EC 3.2.1.24 entry defines alpha-mannosidase by its accepted name and hydrolytic reaction, grounding the enzyme activity named by the organism-level phenotype.
DOI:10.1128/jcm.32.3.854-855.1994
Practically all A. haemolyticum strains (138 of 139) and the Listeria monocytogenes type strain were alpha-mannosidase positive

Carlson and Kontiainen detected alpha-mannosidase in nearly all tested Arcanobacterium haemolyticum strains with a 4-h alpha-mannosidase assay.

Provenance

Identifier source: TraitMech local identifier
Definition source: https://iubmb.qmul.ac.uk/enzyme/EC3/2/1/24.html

Parent traits (1)

phenotype METPO:1000059

kg-microbe context

No kg-microbe node embedding matched this record in the 2026-04-25 deepwalk.

Canonical examples (1)

Organisms cited as exemplars of this trait. Taxon ids are NCBITaxon and link out to the NCBI record.

Arcanobacterium haemolyticum NCBITaxon:28264 DOI:10.1128/jcm.32.3.854-855.1994 Carlson and Kontiainen reported 138 of 139 Arcanobacterium haemolyticum strains as alpha-mannosidase positive in a 4-h test.

Discussions and Knowledge Gaps (1)

Open questions attached to this trait. Seeded by just knowledge-gap-scan and curated; see the corpus-wide index.

Resolve an exact external ontology class for alpha-mannosidase activity before adding a TraitRecord xref.

CURATION TODO OPEN alpha-mannosidase-activity-xref-gap · raised by codex · 2026-09-12

Not yet attached to a section of this record — a curator sets attaches_to (e.g. causal_graphs#some_edge) so the gap shows beside the mechanism it concerns.

GO:0004559 carries the same alpha-mannosidase activity label but denotes the enzyme molecular function rather than the organism-level alpha-mannosidase production phenotype, so it is appropriate as a causal-node grounding rather than an equivalent TraitRecord xref.

Curation history

2026-09-12T00:19:23Z · MINTED_TRAITMECH_ID · codex
Minted alpha-mannosidase activity as a URL/DOI-backed TraitRecord after a repository-wide duplicate review covering ignored and hidden files; METPO has no exact alpha-mannosidase activity class yet.