arginine arylamidase activity

traitmech:000167 · CLASS · PROPOSED

A physiological enzyme-activity phenotype in which a cell exhibits arginine arylamidase/arginyl aminopeptidase activity, releasing N-terminal arginine or lysine residues from peptides or hydrolyzing arginine and lysine arylamides.

Trait evidence (3)

https://iubmb.qmul.ac.uk/enzyme/EC3/4/11/6.html
<b>Reaction:</b> Release of N-terminal Arg and Lys from oligopeptides when P1' is not Pro. Also acts on arylamides of Arg and Lys

The NC-IUBMB EC 3.4.11.6 entry accepts aminopeptidase B, records arginine aminopeptidase, arginyl aminopeptidase, and L-arginine aminopeptidase as other names, and includes arginine and lysine arylamides in the reaction scope.
DOI:10.3389/fgene.2023.1240581
Both of these strains exhibit positive results for oxidase, gamma-glutamyl transferase, alkaline phosphatase, pyrrolidonyl arylamidase, L-arginine arylamidase, and L-aspartate arylamidase

Wang et al. reported both Helicobacter zhangjianzhongii isolates as positive for L-arginine arylamidase in the formal species description.
DOI:10.1099/ijsem.0.006017
arginine arylamidase, proline arylamidase, leucyl glycine arylamidase, phenylalanine arylamidase, leucine arylamidase, tyrosine arylamidase, alanine arylamidase, glycine arylamidase, histidine arylamidase

Srinivasan et al. listed arginine arylamidase among enzymatic activities present in the Amygdalobacter indicium species description, supporting the API arylamidase row as a directly assayed bacterial enzyme-activity phenotype.

Provenance

Identifier source: TraitMech local identifier
Definition source: https://iubmb.qmul.ac.uk/enzyme/EC3/4/11/6.html

Parent traits (1)

phenotype METPO:1000059

Synonyms (5)

L-arginine arylamidase RELATED_SYNONYM · DOI:10.3389/fgene.2023.1240581
aminopeptidase B RELATED_SYNONYM · https://iubmb.qmul.ac.uk/enzyme/EC3/4/11/6.html
arginine aminopeptidase RELATED_SYNONYM · https://iubmb.qmul.ac.uk/enzyme/EC3/4/11/6.html
arginyl aminopeptidase RELATED_SYNONYM · https://iubmb.qmul.ac.uk/enzyme/EC3/4/11/6.html
L-arginine aminopeptidase RELATED_SYNONYM · https://iubmb.qmul.ac.uk/enzyme/EC3/4/11/6.html

kg-microbe context

No kg-microbe node embedding matched this record in the 2026-04-25 deepwalk.

Canonical examples (1)

Organisms cited as exemplars of this trait. Taxon ids are NCBITaxon and link out to the NCBI record.

Helicobacter zhangjianzhongii NCBITaxon:2974574 DOI:10.3389/fgene.2023.1240581 Wang et al. reported both Helicobacter zhangjianzhongii isolates as positive for L-arginine arylamidase in the formal species description.

Discussions and Knowledge Gaps (1)

Open questions attached to this trait. Seeded by just knowledge-gap-scan and curated; see the corpus-wide index.

Resolve an exact external ontology class for arginine arylamidase activity before adding a TraitRecord xref.

CURATION TODO OPEN arginine-arylamidase-activity-xref-gap · raised by codex · 2026-09-12

Not yet attached to a section of this record — a curator sets attaches_to (e.g. causal_graphs#some_edge) so the gap shows beside the mechanism it concerns.

GO:0004177 denotes broad aminopeptidase molecular function, and EC 3.4.11.6 denotes the aminopeptidase B/arginyl aminopeptidase molecular function rather than the organism-level arginine arylamidase assay phenotype. Both remain causal-node grounding leads rather than equivalent TraitRecord xrefs.

Curation history

2026-09-12T11:40:11Z · MINTED_TRAITMECH_ID · codex
Minted arginine arylamidase activity as a URL/DOI-backed TraitRecord after a repository-wide duplicate review covering ignored and hidden files; METPO has no exact arginine arylamidase activity class yet and the placeholder is reserved in proposals/metpo_traitmech_v44.