arginine dihydrolase activity

traitmech:000164 · CLASS · PROPOSED

A physiological pathway-activity phenotype in which a cell converts L-arginine through the arginine deiminase pathway to generate ATP.

Trait evidence (4)

https://iubmb.qmul.ac.uk/enzyme/EC3/5/3/6.html
Reaction: L-arginine + H2O = L-citrulline + NH3

The NC-IUBMB EC 3.5.3.6 entry grounds the first arginine-deiminase step of the arginine deiminase pathway and records arginine dihydrolase as another name for that molecular function.
DOI:10.1016/j.fm.2010.11.016
Arginine conversion through the ADI pathway, which was activated from the stationary growth phase on, resulted in the production of both citrulline and ornithine for all pH conditions tested.

Rimaux et al. directly assayed pH-dependent L-arginine conversion through the ADI pathway in Lactobacillus sakei CTC 494.
DOI:10.1128/aem.07724-11
For instance, the ability to utilize arginine through the arginine deiminase (ADI) pathway, resulting in additional ATP, represents a competitive benefit.

Rimaux et al. frame arginine utilization through the ADI pathway as an ATP-yielding metabolic capability and show that arc gene expression is strain- and pH-dependent in Lactobacillus sakei.
DOI:10.1016/j.resmic.2012.11.004
Arginine conversion through the arginine deiminase (ADI) pathway is a common metabolic trait of Lactobacillus sakei which is ascribed to an arc operon and which inquisitively involves citrulline excretion and re-uptake.

Rimaux et al. use the pathway-activity phrasing while studying the transporter coupled to citrulline and ornithine exchange during L. sakei ADI pathway activity.

Provenance

Identifier source: TraitMech local identifier
Definition source: DOI:10.1128/aem.07724-11

Parent traits (1)

phenotype METPO:1000059

Synonyms (4)

arginine deiminase pathway activity EXACT_SYNONYM · DOI:10.1016/j.resmic.2012.11.004
ADI pathway activity EXACT_SYNONYM · DOI:10.1016/j.resmic.2012.11.004
arginine dihydrolase RELATED_SYNONYM · https://iubmb.qmul.ac.uk/enzyme/EC3/5/3/6.html
arginine deiminase RELATED_SYNONYM · https://iubmb.qmul.ac.uk/enzyme/EC3/5/3/6.html

kg-microbe context

No kg-microbe node embedding matched this record in the 2026-04-25 deepwalk.

Canonical examples (1)

Organisms cited as exemplars of this trait. Taxon ids are NCBITaxon and link out to the NCBI record.

Latilactobacillus sakei NCBITaxon:1599 DOI:10.1016/j.fm.2010.11.016 Rimaux et al. assayed arginine conversion through the ADI pathway in Lactobacillus sakei CTC 494 and observed citrulline and ornithine production across the tested pH series.

Discussions and Knowledge Gaps (1)

Open questions attached to this trait. Seeded by just knowledge-gap-scan and curated; see the corpus-wide index.

Resolve exact external ontology mappings for arginine dihydrolase activity before adding TraitRecord xrefs.

CURATION TODO OPEN arginine-dihydrolase-activity-xref-gap · raised by codex · 2026-09-12

Not yet attached to a section of this record — a curator sets attaches_to (e.g. causal_graphs#some_edge) so the gap shows beside the mechanism it concerns.

GO:0016990 arginine deiminase activity and EC 3.5.3.6 denote the first-step molecular function in the arginine deiminase pathway rather than the full organism-level pathway-activity phenotype, so GO:0016990 is a close mechanism grounding for the source node and not an equivalent TraitRecord xref.

Curation history

2026-09-12T09:44:56Z · MINTED_TRAITMECH_ID · codex
Minted arginine dihydrolase activity as a URL/DOI-backed TraitRecord after a repository-wide duplicate review covering ignored and hidden files; METPO has no exact arginine deiminase pathway activity class yet.