endocytosis

Distinguish membrane-bound uptake from neighboring capabilities.

CURATION TODO OPEN endocytosis-scope-and-hierarchy · raised by codex · 2026-10-06

Not yet attached to a section of this record — a curator sets attaches_to (e.g. causal_graphs#some_edge) so the gap shows beside the mechanism it concerns.

This is the microbial cell's uptake phenotype, not a host response, a sequence feature or intracellular trafficking alone. Surface adsorption, passive diffusion, transporter entry, open membrane invaginations and autophagy alone are insufficient. Pinocytosis traitmech:000635 and phagocytosis traitmech:000627 entail this scope; macropinocytosis traitmech:000634 remains below pinocytosis. No fixed size, clathrin/actin dependence, nutritional assimilation or degradation is required. Trogocytosis traitmech:000633 describes removal and uptake of living-cell portions without universally specifying membrane-bound enclosure. Myzocytosis traitmech:000631 describes prey-content aspiration. Its cited 2023 Discussion (DOI:10.3390/microorganisms11081945) calls myzocytosis a form of endocytosis in the studied Colpodella system; that source-attributed umbrella usage is retained, not treated as proof that every aspiration phenotype meets this operational membrane-bound scope. Their broader parent decisions remain unresolved, not exclusions or disjointness claims. Nutritional phagotrophy is not an equivalent. Review process-level ontology mappings separately; no unverified synonyms or xrefs are asserted.

Resolve strain provenance and route-specific molecular evidence.

KNOWLEDGE GAP OPEN endocytosis-exemplar-and-mechanism · raised by codex · 2026-10-06

Not yet attached to a section of this record — a curator sets attaches_to (e.g. causal_graphs#some_edge) so the gap shows beside the mechanism it concerns.

The two independent studies both concern laboratory Saccharomyces cerevisiae, not independent taxon replication. BHY10.5's reporter background is not a natural isolate; the 1994 full methods and strain provenance remain unread. Canonical examples are left unset rather than generalize these assays to every strain or claim a wild-type provenance. Membrane-tracer transport, receptor uptake and fluid uptake need not report identical routes. The 1995 authors discuss nonvesicular alternatives and qualify endosome identity. No complete molecular mechanism, protein accessions or causal graph are inferred from tracer behavior or abstracts. Obtain taxon-paired functional and strain-provenance evidence before adding those fields.