leucyl glycine arylamidase activity

traitmech:000178 · CLASS · PROPOSED

A physiological enzyme-activity phenotype in which a cell produces active leucyl-glycine arylamidase enzymes that hydrolyze leucyl-glycine arylamide substrates.

Trait evidence (2)

DOI:10.1099/ijsem.0.006017
enzymatic activities are present for: α-galactosidase, N-acetyl-β-glucosaminidase, arginine arylamidase, proline arylamidase, leucyl glycine arylamidase, phenylalanine arylamidase, leucine arylamidase, tyrosine arylamidase, alanine arylamidase, glycine arylamidase, histidine arylamidase, glutamyl glutamic acid arylamidase, serine arylamidase, valine arylamidase, cysteine arylamidase, esterase, esterase lipase, alpha-chymotrypsin

Srinivasan et al. listed leucyl glycine arylamidase among enzymatic activities present in the Amygdalobacter indicium species description, supporting the API arylamidase row as a directly assayed bacterial enzyme-activity phenotype.
DOI:10.1128/JCM.40.9.3427-3431.2002
When the API rapid ID32A system was used, all eight strains displayed activity for alanine arylamidase, arginine arylamidase, α-glucosidase, glycine arylamidase, histidine arylamidase, leucine arylamidase, leucylglycine arylamidase, proline arylamidase, phenylalanine arylamidase, serine arylamidase, and tyrosine arylamidase

Hall et al. reported leucylglycine arylamidase activity in all eight Actinomyces cardiffensis clinical isolates tested with the API rapid ID32A system.

Provenance

Identifier source: TraitMech local identifier
Definition source: DOI:10.1099/ijsem.0.006017

Parent traits (1)

phenotype METPO:1000059

Synonyms (2)

leucyl glycine arylamidase RELATED_SYNONYM · DOI:10.1099/ijsem.0.006017
leucylglycine arylamidase RELATED_SYNONYM · DOI:10.1128/JCM.40.9.3427-3431.2002

kg-microbe context

No kg-microbe node embedding matched this record in the 2026-04-25 deepwalk.

Canonical examples (1)

Organisms cited as exemplars of this trait. Taxon ids are NCBITaxon and link out to the NCBI record.

Amygdalobacter indicium NCBITaxon:3029272 DOI:10.1099/ijsem.0.006017 Srinivasan et al. reported Amygdalobacter indicium as positive for leucyl glycine arylamidase activity in an enzyme activity panel.

Discussions and Knowledge Gaps (1)

Open questions attached to this trait. Seeded by just knowledge-gap-scan and curated; see the corpus-wide index.

Resolve an exact external ontology class for leucyl glycine arylamidase activity before adding a TraitRecord xref.

CURATION TODO OPEN leucyl-glycine-arylamidase-activity-xref-gap · raised by codex · 2026-09-14

Not yet attached to a section of this record — a curator sets attaches_to (e.g. causal_graphs#some_edge) so the gap shows beside the mechanism it concerns.

GO:0016805 covers broad dipeptidase activity at molecular-function scope, and no live GO class provides an exact leucyl-glycine-specific arylamidase production phenotype at organism-level scope.

Curation history

2026-09-14T00:53:00Z · MINTED_TRAITMECH_ID · codex
Minted leucyl glycine arylamidase activity as a DOI-backed TraitRecord after a repository-wide duplicate review covering ignored and hidden files; METPO has no exact leucyl glycine arylamidase activity class yet and the placeholder is reserved in proposals/metpo_traitmech_v55.
2026-09-14T01:12:00Z · UPDATED_DEFINITION · codex
Corrected the PR 882 review wording issue tracked in issue 883 by defining the trait around leucyl-glycine arylamide substrates rather than free leucyl-glycine dipeptide substrates.