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lysine decarboxylase activity

traitmech:000153 · CLASS · PROPOSED

A physiological enzyme-activity phenotype in which a cell produces active lysine decarboxylase enzymes that decarboxylate L-lysine to cadaverine and carbon dioxide.

Trait evidence (2)

  • https://iubmb.qmul.ac.uk/enzyme/EC4/1/1/18.html
    Reaction: L-lysine = cadaverine + CO2

    The NC-IUBMB EC 4.1.1.18 entry defines lysine decarboxylase by its accepted name and reaction from L-lysine to cadaverine and CO2, grounding the enzyme activity named by the organism-level phenotype.

  • DOI:10.1128/jb.01306-06
    Unexpectedly, the tolerance of P(i)-starved cells to fermentation acids was markedly increased as a result of the activity of the inducible CadBA lysine-dependent acid resistance system that consumes one proton and produces the diamine cadaverine.

    Moreau showed that the Escherichia coli inducible CadBA lysine-dependent acid resistance system produces cadaverine during phosphate starvation.

Provenance

Identifier source
TraitMech local identifier
Definition source
https://iubmb.qmul.ac.uk/enzyme/EC4/1/1/18.html

Parent traits (1)

kg-microbe context

No kg-microbe node embedding matched this record in the 2026-04-25 deepwalk.

Canonical examples (1)

Organisms cited as exemplars of this trait. Taxon ids are NCBITaxon and link out to the NCBI record.

Discussions and Knowledge Gaps (1)

Open questions attached to this trait. Seeded by just knowledge-gap-scan and curated; see the corpus-wide index.

Resolve an exact external ontology class for lysine decarboxylase activity before adding a TraitRecord xref.

CURATION TODO OPEN lysine-decarboxylase-activity-xref-gap · raised by codex · 2026-09-12

Not yet attached to a section of this record — a curator sets attaches_to (e.g. causal_graphs#some_edge) so the gap shows beside the mechanism it concerns.

GO:0008923 carries the same lysine decarboxylase activity label but denotes the enzyme molecular function rather than the organism-level lysine decarboxylase production phenotype, so it is appropriate as a causal-node grounding rather than an equivalent TraitRecord xref.

Curation history

  1. · MINTED_TRAITMECH_ID · codex

    Minted lysine decarboxylase activity as a URL/DOI-backed TraitRecord after a repository-wide duplicate review covering ignored and hidden files; METPO has no exact lysine decarboxylase activity class yet.