TraitMech

TraitMech › PHYSIOLOGY

pyrrolidonyl arylamidase activity

traitmech:000155 · CLASS · PROPOSED

A physiological enzyme-activity phenotype in which a cell produces active pyrrolidonyl arylamidase enzymes that release N-terminal pyroglutamyl groups from peptide substrates.

Trait evidence (2)

  • https://iubmb.qmul.ac.uk/enzyme/EC3/4/19/3.html
    Reaction: Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro

    The NC-IUBMB EC 3.4.19.3 entry defines pyroglutamyl-peptidase I by its accepted reaction, grounding the peptidase activity named by the organism-level pyrrolidonyl arylamidase phenotype.

  • DOI:10.1128/JCM.37.11.3443-3447.1999
    The strains displayed acid phosphatase, alkaline phosphatase, ester lipase C8 (weak reaction), esterase C4 (weak reaction), leucine arylamidase, phosphoamidase, and pyrrolidonyl arylamidase activity.

    Collins et al. characterized six Corynebacterium auriscanis isolates that displayed pyrrolidonyl arylamidase activity, supporting this as a directly assayed bacterial enzyme-activity phenotype.

Provenance

Identifier source
TraitMech local identifier
Definition source
https://iubmb.qmul.ac.uk/enzyme/EC3/4/19/3.html

Parent traits (1)

kg-microbe context

No kg-microbe node embedding matched this record in the 2026-04-25 deepwalk.

Canonical examples (1)

Organisms cited as exemplars of this trait. Taxon ids are NCBITaxon and link out to the NCBI record.

Discussions and Knowledge Gaps (1)

Open questions attached to this trait. Seeded by just knowledge-gap-scan and curated; see the corpus-wide index.

Resolve an exact external ontology class for pyrrolidonyl arylamidase activity before adding a TraitRecord xref.

CURATION TODO OPEN pyrrolidonyl-arylamidase-activity-xref-gap · raised by codex · 2026-09-12

Not yet attached to a section of this record — a curator sets attaches_to (e.g. causal_graphs#some_edge) so the gap shows beside the mechanism it concerns.

GO:0016920 denotes pyroglutamyl-peptidase molecular function rather than the organism-level pyrrolidonyl arylamidase production phenotype, so it is appropriate as a causal-node grounding rather than an equivalent TraitRecord xref.

Curation history

  1. · MINTED_TRAITMECH_ID · codex

    Minted pyrrolidonyl arylamidase activity as a URL/DOI-backed TraitRecord after a repository-wide duplicate review covering ignored and hidden files; METPO has no exact pyrrolidonyl arylamidase activity class yet.