NaCl optimum low

Edge evidence

• low ambient NaCl imposes minimal osmoadaptive load

  Low ambient NaCl imposes minimal osmoadaptive demand on the cell.

  • DOI:10.1093/femsre/fuy009 optimal NaCl Supports low-salt environments as the context for non-halophilic optima.
• minimal osmoadaptive load produces NaCl optimum low METPO:2000202

  Minimal osmoadaptive demand yields a low NaCl-optimum setpoint.

  • DOI:10.1093/femsre/fuy009 optimal NaCl Supports low-salt optima as the non-halophile / halotolerant outcome.
• NaCl optimum low is a NaCl optimum rdfs:subClassOf

  NaCl optimum low is a quantitative bin of the NaCl-optimum phenotype.

  • DOI:10.1093/femsre/fuy009 optimal NaCl Supports low-salt optima as a value within the NaCl-optimum distribution.
• non-halophilic optimum NaCl (<0.2 M / ~1% w/v) defined as NaCl optimum low

  Non-halophilic optimum at <0.2 M (~1% w/v) NaCl corresponds to the NaCl-optimum-low trait.

  • DOI:10.3389/fmicb.2019.01895 non-halophilic microorganisms grow optimally at less than 0.2 M (1%) NaCl.
• halotolerant organism is a non-halophilic optimum NaCl (<0.2 M / ~1% w/v) rdfs:subClassOf

  Halotolerant organisms are non-halophiles (low-NaCl optimum) able to grow at high salt.

  • DOI:10.1007/s40201-020-00519-3 halotolerant organisms are those non-halophilic able to grow at high salt concentrations.
• compatible solute accumulation supports osmotic stress adaptation

  Accumulation of compatible solutes supports adaptation to osmotic stress.

  • DOI:10.1128/aem.00619-25 Bacteria respond to osmotic stress by intracellularly accumulating compatible solutes.
• minimal osmoadaptive load reduces demand for compatible solute accumulation

  At low ambient NaCl, minimal osmoadaptive load reduces the need for compatible-solute accumulation.

  • DOI:10.1128/aem.00619-25 Compatible solutes are accumulated in response to osmotic stress; low salt imposes minimal such demand.
• cyclic di-AMP inhibits K+ uptake systems (Trk/Ktr/Kup/KimA) RO:0002212

  Cyclic di-AMP binds gating subunits of Trk/Ktr/Kup/KimA and inhibits K+ uptake.

  • DOI:10.1128/mmbr.00181-23 gating subunits of Trk/Ktr bind cyclic di-AMP; KUP-family activity is inhibited by cyclic di-AMP.
• cyclic di-AMP negatively regulates OpuA/OpuC compatible-solute transporters

  Cyclic di-AMP binds OpuA/OpuC importers and negatively regulates compatible-solute transport.

  • DOI:10.1128/mmbr.00181-23 c-di-AMP binds CBS and RCK_C domains of OpuA/OpuC and negatively regulates their transport activity.