pH delta high

Edge evidence

• maximal pH-homeostasis flexibility produces pH delta high METPO:2000202

  Maximal pH-homeostasis flexibility yields an extreme pH-delta breadth.

  • DOI:10.1016/j.tim.2007.02.005 proton motive force Supports maximal pH-homeostasis flexibility as the basis of euryphilic breadth.
• pH delta high is a pH delta rdfs:subClassOf

  pH delta high is a quantitative bin of the pH-delta phenotype.

  • DOI:10.1038/nrmicro2549 pH homeostasis Supports the 5–9 unit breadth as a value within the pH-delta distribution.
• Na+/H+ antiporters contributes to pH delta high RO:0002326

  Na+/H+ antiport is a core regulator of cytoplasmic pH across changing external pH.

  • DOI:10.1093/femsre/fuad033 Key regulators of bacterial pH homeostasis are Na+/H+ and K+/H+ antiporters.
• respiratory proton-pumping enzymes helps maintain cytoplasmic pH homeostasis

  Electron-transport proton pumps counteract pH stress by controlling proton flux.

  • DOI:10.1093/femsre/fuad033 Proton-pumping enzymes (electron transport components) are major homeostasis regulators.
• F0F1-ATPase contributes to pH delta high RO:0002326

  F0F1-ATPase participates in pH homeostasis via proton extrusion or uptake.

  • DOI:10.1093/femsre/fuad033 F0F1-ATPase is named among key regulators of bacterial pH homeostasis.
• metabolite decarboxylation pathways contributes to pH delta high RO:0002326

  Proton-consuming decarboxylation pathways support broad pH tolerance.

  • DOI:10.1093/femsre/fuad033 Metabolite decarboxylation pathways are key regulators of pH homeostasis.
• cytoplasmic buffering capacity stabilizes cytoplasmic pH homeostasis

  High buffering capacity limits pH swings, enabling broader pH tolerance.

  • DOI:10.1093/femsre/fuad033 Internal pH kept ~7.0-7.5 as buffers absorb fluctuations.
• near-neutral cytoplasmic pH enables growth across external pH 5.5-9.0 RO:0002327

  Neutralophiles maintain narrow internal pH while growing over a broad external range.

  • DOI:10.1038/nrmicro2549 Neutralophiles grow at external pH ~5.5-9.0 while maintaining cytoplasmic pH ~7.5-7.7.
• constant proton motive force supports pH delta high

  A relatively constant PMF across external pH is a hallmark of broad pH tolerance.

  • DOI:10.1093/femsre/fuad033 PMF of neutralophilic bacteria kept relatively constant over pH 5 to 8.
• membrane lipid/porin composition changes reduces inward proton leakage METPO:2000017

  Membrane/porin composition changes lower proton leak during acid stress.

  • DOI:10.1038/nrmicro2549 Membrane lipid and porin composition changes minimize inward proton leakage during acid stress.