pH optimum mid2

Edge evidence

• slightly alkaline external pH engages modest alkaline pH homeostasis

  Slightly alkaline external pH engages modest alkaline pH-homeostasis.

  • DOI:10.1016/j.tim.2007.02.005 proton motive force Supports balanced proton motive force at slightly alkaline pH as the energetic setting of this regime.
• modest alkaline pH homeostasis produces pH optimum mid2 METPO:2000202

  Modest alkaline pH-homeostasis yields a neutrophile / alkaline-tolerant pH-optimum setpoint.

  • DOI:10.1038/nrmicro2549 pH homeostasis Supports the 7–8 optimum as the neutrophile / mild-alkaliphile outcome.
• pH optimum mid2 is a pH optimum rdfs:subClassOf

  pH optimum mid2 is a quantitative bin of the pH-optimum phenotype.

  • DOI:10.1038/nrmicro2549 cytoplasmic pH Supports the 7–8 optimum as a value within the pH-optimum distribution.
• cytoplasmic buffering capacity stabilizes intracellular pH homeostasis

  Cytoplasmic buffering capacity stabilizes intracellular pH against fluctuations.

  • DOI:10.1093/femsre/fuad033 Buffering capacity of the cytoplasm absorbs pH fluctuations; broad bacterial mechanism supporting near-neutral pHi at external pH 7-8.
• Na+/H+ antiporters maintains intracellular pH homeostasis

  Na+/H+ antiporters acidify the cytoplasm when pHi is too high, maintaining pH homeostasis.

  • DOI:10.1093/femsre/fuad033 Proton-sensing antiporters acidify the cytoplasm by exporting Na+ for protons when internal pH gets too high; general mechanism relevant at external pH 7-8.
• K+/H+ antiporters regulates intracellular pH homeostasis RO:0002211

  K+/H+ antiporters are key regulators of bacterial internal pH.

  • DOI:10.1093/femsre/fuad033 Na+/H+ and K+/H+ antiporters are key regulators of bacterial pH homeostasis; general regulator.
• proton-pumping respiratory chain components maintains intracellular pH homeostasis

  Proton-pumping respiratory chain components prevent the internal pH from becoming too low.

  • DOI:10.1093/femsre/fuad033 Activation of proton-pumping respiratory chains prevents internal pH becoming too low; broad statement across respiratory bacteria.
• metabolite decarboxylation pathways generates proton motive force biolink:produces

  Metabolite decarboxylation pathways store free energy as proton motive force.

  • DOI:10.1093/femsre/fuad033 The free energy change from decarboxylation reactions can be stored as a proton motive force; general, not taxon-specific.
• proton motive force powers F0F1-ATP synthase

  Proton motive force powers F0F1-ATP synthase ATP synthesis.

  • DOI:10.1093/femsre/fuad033 The proton motive force can be used by F0F1-ATP synthase to make ATP; strong general bioenergetic edge.