temperature delta mid2

METPO:1000486 · CLASS · REVIEWED

A temperature delta phenotype with a growth-supporting temperature breadth of approximately 20–30 °C, characteristic of organisms with broad thermal-tolerance breadth.

Temperature-delta-mid2 broad-breadth thermal adaptation

DOI-backed graph linking broad thermal-adaptation flexibility to a 20–30 °C temperature growth breadth.

Temperature-delta-mid2 broad-breadth thermal adaptation Interactive directed graph showing evidence-backed causal relationships for temperature delta mid2.

Edge evidence

  • broad thermal-adaptation flexibility produces temperature delta mid2 METPO:2000202

    Broad thermal-adaptation flexibility yields a 20–30 °C temperature-delta breadth.

    • DOI:10.1146/annurev-micro-091313-103612 more unsaturated fatty acids Supports broad remodeling flexibility as the basis of broad breadth.
  • temperature delta mid2 is a temperature delta rdfs:subClassOf

    Temperature delta mid2 is a quantitative bin of the temperature-delta phenotype.

    • DOI:10.1016/s0300-9629(97)00003-0 adapted to environments of high temperature Supports the 20–30 °C breadth as a value within the temperature-delta distribution.
  • acyl-lipid desaturase (Des) increases abundance of unsaturated fatty acids

    Desaturase remodels existing lipids, raising unsaturated:saturated fatty acid ratio.

    • DOI:10.1128/spectrum.03925-23 A rapid change in the saturated:unsaturated fatty acid ratio by desaturation of existing lipids.
  • unsaturated fatty acids increases membrane fluidity / homeoviscous adaptation RO:0002213

    Unsaturation fluidizes the membrane, supporting homeoviscous adaptation.

    • DOI:10.1128/spectrum.03925-23 Desaturation fluidizes the membrane; strong general mechanism.
  • membrane fluidity / homeoviscous adaptation enables broad thermal-adaptation flexibility RO:0002327

    Maintaining membrane fluidity across temperatures underpins broad thermal-adaptation flexibility.

    • DOI:10.1128/spectrum.03925-23 Homeoviscous adaptation via fluidity maintenance underlies adaptation across a temperature range.
  • RpoS sigma factor (sigma-S) positively regulates expression of otsAB trehalose biosynthesis operon

    RpoS controls cold-shock-triggered induction of the otsAB operon.

    • DOI:10.1007/s12275-023-00031-x otsAB induction is RpoS-dependent and triggered by osmotic stress, cold shock, or stationary phase.
  • otsAB trehalose biosynthesis operon produces trehalose METPO:2000202

    The otsAB pathway synthesizes trehalose.

    • DOI:10.1007/s12275-023-00031-x Trehalose is synthesized by the otsAB operon.
  • trehalose contributes to cold / cold-shock tolerance RO:0002326

    Trehalose acts as a compatible solute supporting cold-shock tolerance.

    • DOI:10.1007/s12275-023-00031-x Trehalose helps cold shock tolerance.

Provenance

Source
METPO (2025-11-25)
Definition source
DOI:10.1146/annurev-micro-091313-103612

Synonyms (1)

  • Td_20_30 RELATED_SYNONYM · metpo.owl

kg-microbe context

Matched 1 kg-microbe node via direct_metpo.

  • METPO:1000486 [-3.073, +0.032, -2.627, +2.668, …]

512-dim DeepWalkSkipGramEnsmallen embedding from kg-microbe (2026-04-25).

Nearest neighbors in embedding space

Top-8 cosine-similar METPO traits from the 2026-04-25 deepwalk (512-D).

Curation history

  1. · SEEDED_FROM_METPO · seed_from_metpo

    imported from data/raw/metpo.owl (CLASS)

  2. · CURATED_CAUSAL_GRAPH · claude

    Added DOI-backed definition and causal graph linking broad thermal-adaptation flexibility to the temperature-delta-mid2 bin.

  3. · GROUND_CAUSAL_PREDICATES · claude

    Grounded 2 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (METPO:2000202×1, rdfs:subClassOf×1).

  4. · ENRICH_CAUSAL_GRAPH · claude

    Added 6 evidence-backed generic edges (7 new nodes) from the deep-research report.

  5. · GROUND_CAUSAL_PREDICATES · claude

    Grounded 4 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (RO:0002213×1, RO:0002327×1, METPO:2000202×1, RO:0002326×1).

  6. · GROUND_CAUSAL_NODES · claude

    Grounded 1 causal-node grounding field(s) via mappings/node_grounding.tsv (CHEBI:27208×1).