pH delta low

Edge evidence

• limited pH-homeostasis flexibility produces pH delta low METPO:2000202

  Limited pH-homeostasis flexibility yields a 1–2 pH-unit pH-delta breadth.

  • DOI:10.1038/nrmicro2549 pH homeostasis Supports limited pH-homeostasis flexibility as the basis of narrow breadth.
• pH delta low is a pH delta rdfs:subClassOf

  pH delta low is a quantitative bin of the pH-delta phenotype.

  • DOI:10.1016/j.tim.2007.02.005 proton motive force Supports the 1–2 unit breadth as a value within the pH-delta distribution.
• external pH stress challenges cytoplasmic pH homeostasis METPO:2007406

  External pH outside the maintainable cytoplasmic range challenges pH homeostasis.

  • DOI:10.1038/nrmicro2549 Diverse mechanisms for pH sensing and cytoplasmic pH homeostasis enable most bacteria to tolerate external pH outside the cytoplasmic range; general across bacteria.
• proton motive force architecture determines pH homeostasis capacity

  PMF architecture (Delta-psi and Delta-pH balancing) determines pH homeostasis capacity.

  • DOI:10.1038/nrmicro2549 Bacteria tune and even reverse the relative magnitudes of Delta-psi and Delta-pH under pH stress; strong general mechanistic edge.
• weak organic acids perturbs delta pH / cytoplasmic pH

  Weak organic acids cross the membrane and perturb the proton gradient / cytoplasmic pH.

  • DOI:10.1038/nrmicro2549 Uncharged weak-acid forms cross membranes and become trapped when charged, perturbing Delta-pH; general chemical-factor edge.
• electrogenic Na+/H+ antiport supports alkaline pH homeostasis

  Electrogenic Na+/H+ antiport supports cytoplasmic pH homeostasis under alkaline stress.

  • DOI:10.1038/nrmicro2549 Under alkaline stress, inward proton transport through cation/proton antiporters is crucial; strong general transporter-mediated edge.
• F1Fo-ATPase contributes to cytoplasmic pH homeostasis RO:0002326

  F1Fo-ATPase contributes to cytoplasmic pH homeostasis by expelling or importing H+.

  • DOI:10.1038/nrmicro2549 Respiratory complexes and proton-coupled ATPases use or generate PMF to expel or import H+; general higher-level edge.