temperature delta high

Edge evidence

• maximal thermal-adaptation flexibility produces temperature delta high METPO:2000202

  Maximal thermal-adaptation flexibility yields an extreme temperature-delta breadth.

  • DOI:10.1128/MMBR.65.1.1-43.2001 resistant to irreversible inactivation at high temperatures Supports maximal thermal-adaptation as the basis of extreme eurythermal breadth.
• temperature delta high is a temperature delta rdfs:subClassOf

  Temperature delta high is a quantitative bin of the temperature-delta phenotype.

  • DOI:10.1146/annurev-micro-091313-103612 more unsaturated fatty acids Supports the >30 °C breadth as a value within the temperature-delta distribution.
• decreased growth temperature increases unsaturated fatty acid biosynthesis RO:0002213

  Lower growth temperature increases incorporation of unsaturated fatty acids (homoviscous adaptation).

  • DOI:10.1146/annurev-micro-091313-103612 Bacteria remodel membrane fluidity via proportionally more unsaturated fatty acids as growth temperature decreases.
• homoviscous adaptation maintains membrane fluidity homeostasis

  Homoviscous adaptation maintains membrane fluidity/permeability homeostasis across thermal shifts.

  • DOI:10.1146/annurev-micro-091313-103612 Homoviscous adaptation disrupts lipid bilayer order and optimizes cellular processes at the new temperature.
• decreased membrane fluidity upregulates unsaturated fatty acid biosynthesis

  Reduced membrane fluidity is sensed and upregulates unsaturated fatty acid biosynthesis.

  • DOI:10.1146/annurev-micro-091313-103612 Microbes sense decreased membrane fluidity and initiate responses that upregulate unsaturated fatty acid biosynthesis.
• lipid desaturase activity increases membrane fluidity RO:0002213

  Lipid desaturases introduce cis double bonds (~30 deg kink) creating packing defects that increase fluidity.

  • DOI:10.3390/cells12101353 Organisms maintain membrane fluidity by activating lipid desaturases that introduce cis double bonds to increase packing defects and fluidity.
• cis-trans isomerase activity increases membrane viscosity at higher temperature RO:0002213

  Cis-trans isomerization of existing UFAs yields trans-UFAs resembling SFAs, raising membrane viscosity during warming.

  • DOI:10.3390/cells12101353 Cis-trans isomerase converts UFAs; trans-UFAs resemble SFAs and raise membrane viscosity, compensating at higher temperature.
• increased short-/branched-/unsaturated fatty acids increases membrane fluidity RO:0002213

  Shifts in acyl chain length/branching and unsaturation jointly increase membrane fluidity at lower temperatures.

  • DOI:10.3390/cells12101353 Membrane composition adjustments (SCFA, BCFA, unsaturation, lysophospholipids) can increase membrane fluidity at lower temperatures.
• hyperthermophilic enzyme thermostability resists irreversible inactivation at high temperatures

  Intrinsic enzyme thermostability resists irreversible inactivation, extending upper growth limits.

  • DOI:10.1128/MMBR.65.1.1-43.2001 Enzymes from hyperthermophiles are typically thermostable, i.e., resistant to irreversible inactivation at high temperatures.