temperature range high

Edge evidence

• thermophile thermostability enables temperature range high RO:0002327

  Thermophile thermostability enables growth at > 40 °C.

  • DOI:10.1128/MMBR.65.1.1-43.2001 resistant to irreversible inactivation at high temperatures Supports thermostability as the range mechanism for thermophile physiology.
• temperature range high is a temperature range rdfs:subClassOf

  Temperature range high is a quantitative bin of the temperature-range phenotype.

  • DOI:10.1016/s0300-9629(97)00003-0 adapted to environments of high temperature Supports the >40 °C range as a value within the temperature-range distribution.
• reverse gyrase (TopR/rgy) introduces positive DNA supercoiling

  Reverse gyrase introduces positive supercoils into DNA.

  • DOI:10.1264/jsme2.me23087 reverse gyrase, a unique topoisomerase that introduces positive supercoils into DNA; broadly applicable to thermophiles.
• positive DNA supercoiling limits DNA melting RO:0002212

  Positive DNA supercoiling limits thermal melting of DNA.

  • DOI:10.1264/jsme2.me23087 maintain the genome integrity of thermophiles by limiting DNA melting; general for reverse-gyrase-bearing thermophiles.
• reverse gyrase (TopR/rgy) enables temperature range high RO:0002327

  Reverse gyrase activity supports growth at high temperature via genome stabilization.

  • DOI:10.1128/mbio.02174-23 Reverse gyrase reported as essential for growth at very high temperature, maintaining DNA stability.
• DnaK-DnaJ chaperone assists protein folding

  DnaK-DnaJ assists ATP-dependent folding of nascent and unfolded proteins.

  • DOI:10.1007/s12275-023-00031-x DnaK-DnaJ assist ATP-dependent folding of nascent and unfolded peptides; bacterial high-temperature response.
• GroEL-GroES / HtpG chaperone assists protein folding

  GroEL-GroES and HtpG assist protein folding under heat stress.

  • DOI:10.1007/s12275-023-00031-x GroEL-GroES, HtpG assist protein folding under heat stress; broadly relevant heat response.
• protein folding maintains proteostasis at high temperature

  Chaperone-assisted folding maintains proteostasis at high temperature.

  • DOI:10.1128/mbio.02174-23 refolding/degradation systems counter protein denaturation, aggregation and loss of function during heat shock.
• proteostasis at high temperature enables temperature range high RO:0002327

  Proteostasis at high temperature supports growth above 40 C.

  • DOI:10.1128/mbio.02174-23 proteostasis machinery supports thermophile survival/growth at high temperature.