NaCl range

Edge evidence

• ambient NaCl concentration defines bounded growth window METPO:2007500

  Ambient NaCl defines the axis over which the growth window is bounded.

  • DOI:10.1093/femsre/fuy009 salinity range Supports NaCl as the axis bounding the growth window.
• low-salt tolerance defines bounded growth window METPO:2007500

  Tolerance to low salt sets the lower bound of the growth window.

  • DOI:10.1186/1746-1448-4-2 cope with the high salt concentrations Saline-Systems review frames halophily around salt-tolerance mechanisms that span both the lower and upper limits of growth-supporting salinity.
• high-salt tolerance defines bounded growth window METPO:2007500

  Tolerance to high salt sets the upper bound of the growth window.

  • DOI:10.1093/femsre/fuy009 high salt concentrations Supports tolerance to high salt as the upper-bound mechanism.
• bounded growth window manifests as NaCl range METPO:2007400

  The bounded growth window manifests the NaCl-range phenotype.

  • DOI:10.1093/femsre/fuy009 salinity range Supports the trait endpoint.
• cyclic di-AMP inhibits Trk/Ktr potassium influx systems RO:0002212

  c-di-AMP binds gating subunits of Trk/Ktr systems, inhibiting potassium influx.

  • DOI:10.1128/MMBR.00181-23 TrkAH, KtrAB and KtrCD gating subunits bind c-di-AMP, inhibiting potassium influx (Foster et al. 2024, review across multiple bacteria).
• cyclic di-AMP inhibits KimA/Kup high-affinity K+ uptake transporters RO:0002212

  c-di-AMP directly inhibits high-affinity K+ uptake transporters KimA and Kup.

  • DOI:10.1128/MMBR.00181-23 High-affinity transporters (KimA, KupA/KupB) are inhibited directly by cyclic di-AMP, affecting K+ homeostasis underlying NaCl limits.
• cyclic di-AMP inhibits Kdp system / KdpFABC expression RO:0002212

  c-di-AMP binding to KdpD inhibits kdpFABC transcription.

  • DOI:10.1128/MMBR.00181-23 KdpD binding of cyclic di-AMP inhibits kdpFABC transcription (Foster et al. 2024 review).
• cyclic di-AMP regulates OpuA-like compatible-solute importers RO:0002211

  c-di-AMP binds and regulates OpuA-like compatible-solute importers.

  • DOI:10.1128/MMBR.00181-23 c-di-AMP binds OpuA-like ABC compatible-solute importers, linking the regulatory module to osmolyte accumulation.
• cyclic di-AMP reduces high-salt tolerance METPO:2000017

  Elevated c-di-AMP correlates with salt sensitivity and narrower NaCl tolerance.

  • DOI:10.1128/MMBR.00181-23 High cyclic di-AMP levels correlate with salt sensitivity, narrowing salt tolerance via suppressed K+ uptake (Foster et al. 2024 review).