NaCl range low

Edge evidence

• limited high-salt tolerance produces NaCl range low METPO:2000202

  Limited tolerance to elevated NaCl caps growth at low salt.

  • DOI:10.1093/femsre/fuy009 salinity range Supports limited high-salt tolerance as the basis of a low NaCl range.
• NaCl range low is a NaCl range rdfs:subClassOf

  NaCl range low is a quantitative bin of the NaCl-range phenotype.

  • DOI:10.1093/femsre/fuy009 salinity range Supports low NaCl range as a value within the NaCl-range distribution.
• NaCl concentration causes hyperosmotic stress biolink:causes

  Increased external NaCl concentration causes hyperosmotic stress.

  • DOI:10.1093/femsml/uqad020 Hyperosmotic upshift elicits rapid K+ import as an emergency response; general bacterial osmotic-stress edge.
• hyperosmotic stress induces compatible solute accumulation

  Hyperosmotic stress induces accumulation of compatible solutes.

  • DOI:10.1093/femsml/uqad020 After K+ import, cells synthesize or import compatible solutes and export K+ to reduce cytoplasmic ionic strength.
• hypoosmotic shock opens mechanosensitive channels MscL/MscS

  Hypoosmotic shock opens mechanosensitive channels MscL/MscS to prevent rupture.

  • DOI:10.1093/femsml/uqad020 Hypoosmotic shock triggers transient opening of mechanosensitive channels (MscL/MscS) to prevent turgor-driven cell rupture; broad across bacteria.
• cyclic di-AMP inhibits OpuA/OpuC compatible-solute importers RO:0002212

  c-di-AMP binds and inhibits OpuA/OpuC compatible-solute importers.

  • DOI:10.1128/mmbr.00181-23 c-di-AMP binds CBS-containing importers (OpuA/OpuC) and negatively regulates their transport activity.
• choline uptake enables glycine betaine biosynthesis RO:0002327

  Choline uptake enables synthesis of glycine betaine, a key compatible solute.

  • DOI:10.1126/sciadv.ado6229 BetT mediates uptake of external choline used to synthesize glycine betaine, a key compatible solute in hyperosmotic environments.