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NaCl delta mid2

METPO:1000481 · CLASS · REVIEWED

A NaCl delta phenotype with a growth-supporting NaCl breadth of approximately 3–8% (w/v), characteristic of organisms with broad salinity tolerance.

NaCl-delta-mid2 broad-breadth osmoadaptation

DOI-backed graph linking robust osmoadaptive flexibility to a 3–8% (w/v) NaCl growth breadth.

NaCl-delta-mid2 broad-breadth osmoadaptation Interactive directed graph showing evidence-backed causal relationships for NaCl delta mid2.

Edge evidence

  • robust osmoadaptive flexibility produces NaCl delta mid2 METPO:2000202

    Robust osmoadaptive flexibility yields a 3–8% NaCl-delta breadth.

    • DOI:10.1093/femsre/fuy009 salinity range Supports robust osmoadaptive flexibility as the basis of a broad breadth.
  • NaCl delta mid2 is a NaCl delta rdfs:subClassOf

    NaCl delta mid2 is a quantitative bin of the NaCl-delta phenotype.

    • DOI:10.1093/femsre/fuy009 salinity range Supports the 3–8% breadth as a value within the NaCl-delta distribution.
  • cyclic di-AMP inhibits potassium uptake systems RO:0002212

    c-di-AMP binding to transporters/riboswitches inhibits K+ import.

    • DOI:10.1128/mmbr.00181-23 Binding of c-di-AMP to transporters and riboswitches inhibits potassium import (KupA/KupB, KimA, kdp operon).
  • cyclic di-AMP modulates cell volume regulation RO:0002211

    c-di-AMP signaling acts as a master regulator of cell volume.

    • DOI:10.1128/mmbr.00181-23 Review argues cyclic di-AMP is a master regulator of cell volume.
  • osmolality upregulates KdpFABC complex

    Elevated osmolality upregulates kdpFABC expression.

    • DOI:10.1128/mmbr.00181-23 Osmolality upregulates kdpFABC expression (review-level, broadly useful).
  • compatible-solute accumulation/transport causes osmoprotection biolink:causes

    Accumulation/transport of compatible solutes confers osmoprotection.

    • DOI:10.1111/mec.16316 Compatible-solute biosynthesis/uptake and transporter genes -> osmotic protection.
  • exopolysaccharide matrix binds sodium ion

    The EPS matrix binds Na+ cations.

    • DOI:10.1093/femsre/fuaf020 The EPS matrix binds cations such as Na+ ions.
  • exopolysaccharide matrix promotes water retention / reduced pericellular Na+ toxicity RO:0002213

    EPS matrix promotes water retention and reduces pericellular Na+ toxicity.

    • DOI:10.1093/femsre/fuaf020 Lowering effective pericellular Na+ and retaining water.

Provenance

Source
METPO (2025-11-25)
Definition source
DOI:10.1093/femsre/fuy009

Parent traits (1)

Synonyms (1)

  • Nad_3_8 RELATED_SYNONYM · metpo.owl

kg-microbe context

Matched 1 kg-microbe node via direct_metpo.

  • METPO:1000481 [-2.652, -0.385, +1.033, +2.032, …]

512-dim DeepWalkSkipGramEnsmallen embedding from kg-microbe (2026-04-25).

Nearest neighbors in embedding space

Top-8 cosine-similar METPO traits from the 2026-04-25 deepwalk (512-D).

Curation history

  1. · SEEDED_FROM_METPO · seed_from_metpo

    imported from data/raw/metpo.owl (CLASS)

  2. · CURATED_CAUSAL_GRAPH · claude

    Added DOI-backed definition and causal graph linking robust osmoadaptive flexibility to the broad-breadth NaCl-delta bin.

  3. · GROUND_CAUSAL_PREDICATES · claude

    Grounded 2 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (METPO:2000202×1, rdfs:subClassOf×1).

  4. · ENRICH_CAUSAL_GRAPH · claude

    Added 6 evidence-backed generic edges (10 new nodes) from the deep-research report.

  5. · GROUND_CAUSAL_PREDICATES · claude

    Grounded 4 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (RO:0002212×1, RO:0002211×1, biolink:causes×1, RO:0002213×1).

  6. · GROUND_CAUSAL_NODES · claude

    Grounded 2 causal-node grounding field(s) via mappings/node_grounding.tsv (CHEBI:71578×1, CHEBI:29101×1).