temperature optimum mid2

METPO:1000444 · CLASS · REVIEWED

A temperature optimum phenotype with the best-growth ambient temperature between approximately 27 and 30 °C, characteristic of mesophilic physiology.

Temperature-optimum-mid2 mesophile setpoint

DOI-backed graph linking baseline mesophile adaptation to a temperature optimum between 27 and 30 °C.

Temperature-optimum-mid2 mesophile setpoint Interactive directed graph showing evidence-backed causal relationships for temperature optimum mid2.

Edge evidence

  • mesophilic environment engages baseline mesophile adaptation

    Mesophilic environments engage baseline mesophile adaptation.

    • DOI:10.1146/annurev-micro-091313-103612 more unsaturated fatty acids Supports mesophile homoviscous adaptation at moderate ambient temperature.
  • baseline mesophile adaptation produces temperature optimum mid2 METPO:2000202

    Baseline mesophile adaptation yields a 27–30 °C optimum.

    • DOI:10.1146/annurev-micro-091313-103612 more unsaturated fatty acids Supports the 27–30 °C optimum as the baseline-mesophile outcome.
  • temperature optimum mid2 is a temperature optimum rdfs:subClassOf

    Temperature optimum mid2 is a quantitative bin of the temperature-optimum phenotype.

    • DOI:10.1016/s0300-9629(97)00003-0 adapted to environments of high temperature Supports the 27–30 °C optimum as a value within the temperature-optimum distribution.
  • temperature decrease causes membrane rigidification biolink:causes

    A temperature drop rigidifies and thickens the cytoplasmic membrane.

    • DOI:10.1128/spectrum.03925-23 Temperature drops cause membrane rigidification and thickening and can induce a liquid-crystalline to gel phase change; general bacterial mechanism.
  • unsaturated fatty acids increases membrane fluidity RO:0002213

    Higher unsaturated fatty acid content fluidizes and thins the bilayer.

    • DOI:10.1007/s42770-023-01057-4 Increasing the saturated/unsaturated ratio toward UFAs increases fluidity; UFAs are central membrane fluidizers.
  • baseline mesophile adaptation increases unsaturated fatty acids RO:0002213

    Homeoviscous mesophile adaptation raises unsaturated fatty acid content to offset cooling.

    • DOI:10.1007/s42770-023-01057-4 Homeoviscous adaptation adjusts the saturated/unsaturated fatty-acid ratio to maintain membrane fluidity at the growth temperature.
  • membrane fluidity enables baseline mesophile adaptation RO:0002327

    Maintained membrane fluidity supports the baseline mesophile physiological state.

    • DOI:10.1128/spectrum.03925-23 Cells sense and correct membrane fluidity via desaturation to keep the bilayer functional at the ambient temperature.
  • temperature optimum mid2 subclass of mesophile category

    The 27-30 C optimum falls within the mesophile growth range.

    • DOI:10.1007/s42770-023-01057-4 Mesophiles grow between about 20 C and 45 C; 27-30 C lies inside this range, making mid2 a mesophile subset.

Provenance

Source
METPO (2025-11-25)
Definition source
DOI:10.1146/annurev-micro-091313-103612

Synonyms (2)

  • Mesophilie EXACT_SYNONYM · metpo.owl
  • TO_27_to_30 RELATED_SYNONYM · metpo.owl

kg-microbe context

Matched 1 kg-microbe node via direct_metpo.

  • METPO:1000444 [-3.661, -4.062, -0.551, +2.283, …]

512-dim DeepWalkSkipGramEnsmallen embedding from kg-microbe (2026-04-25).

Nearest neighbors in embedding space

Top-8 cosine-similar METPO traits from the 2026-04-25 deepwalk (512-D).

Curation history

  1. · SEEDED_FROM_METPO · seed_from_metpo

    imported from data/raw/metpo.owl (CLASS)

  2. · CURATED_CAUSAL_GRAPH · claude

    Added DOI-backed definition and causal graph linking baseline mesophile adaptation to the temperature-optimum-mid2 bin.

  3. · GROUND_CAUSAL_PREDICATES · claude

    Grounded 2 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (METPO:2000202×1, rdfs:subClassOf×1).

  4. · ENRICH_CAUSAL_GRAPH · claude

    Added 5 evidence-backed generic edges (5 new nodes) from the deep-research report.

  5. · GROUND_CAUSAL_PREDICATES · claude

    Grounded 4 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (RO:0002213×2, biolink:causes×1, RO:0002327×1).

  6. · GROUND_CAUSAL_NODES · claude

    Grounded 1 causal-node grounding field(s) via mappings/node_grounding.tsv (METPO:1007505×1).

  7. · GROUND_CAUSAL_NODES · claude

    Grounded 1 causal-node grounding field(s) via mappings/node_grounding.tsv (CHEBI:27208×1).