slightly halophilic

Edge evidence

• low to moderate NaCl enables slightly halophilic RO:0002327

  Slight halophily is a salt-growth preference at lower salinity than moderate or extreme halophily.

  • DOI:10.1186/1746-1448-4-2 minimum salt concentration required for growth Review supports halophily as a continuum of salt growth requirements.
• low to moderate NaCl causes osmotic stress biolink:causes

  Even lower salinity preferences involve osmotic adjustment to environmental salt.

  • DOI:10.1186/1746-1448-4-2 salt relationships Review describes growth in relation to minimum, optimum, and upper salt limits.
• compatible solutes mitigates osmotic stress METPO:2007407

  Compatible solutes provide osmotic balance without disrupting metabolism.

  • DOI:10.1371/journal.pone.0168818 do not disturb the cell's metabolism Supports compatible solutes as non-disruptive osmoprotectants.
• osmoprotectant transport accumulates compatible solutes METPO:2000210

  Uptake systems can accumulate compatible solutes for salt adaptation.

  • DOI:10.1093/femsre/fuy009 organic osmotic solutes Review supports accumulation of organic osmotic solutes in bacterial osmoadaptation.
• ectABC/ectBACD gene cluster enables ectoine biosynthesis RO:0002327

  The ect gene cluster encodes the enzymes that carry out ectoine biosynthesis.

  • DOI:10.1128/aem.01905-23 ectoine biosynthesis genes are denoted by ectABC; ectBACD up-regulated as an osmoadaptation system.
• ectoine biosynthesis produces ectoine METPO:2000202

  Ectoine biosynthesis produces the compatible solute ectoine.

  • DOI:10.1128/aem.01905-23 Wild-type accumulates ectoine as its major osmolyte via the ectABC pathway.
• ectoine increases salt tolerance RO:0002213

  Accumulation of ectoine as a compatible solute increases salt tolerance.

  • DOI:10.1128/aem.01905-23 Wild-type accumulates ectoine as its major osmolyte while the ectABC-deleted strain is salt-sensitive.
• osmoprotectant transport increases salt tolerance RO:0002213

  Uptake of compatible solutes is a general salt-out osmoadaptation strategy that raises salt tolerance.

  • DOI:10.1093/femsre/fuy026 Salt-out strategists exclude salt and/or synthesize or uptake compatible solutes (e.g. glycine betaine); dominant strategy in many halophilic bacteria.
• Na+/K+ transcriptional induction supports ion homeostasis during salt stress

  Coordinated induction of Na+/K+ transcription supports ion homeostasis during salt stress.

  • DOI:10.1038/s42003-022-04319-3 Coordinated induction of Na+/K+ transcription and ectoine, proline, and betaine biosynthesis under salt stress.