halotolerant

Edge evidence

• high-salt exposure tolerated by halotolerant

  Halotolerant organisms can survive elevated salinity without requiring it.

  • DOI:10.1093/femsre/fuy009 highly halotolerant representatives Review distinguishes halotolerant microorganisms in high-salt environments.
• high-salt exposure causes osmotic stress biolink:causes

  External salinity creates osmotic stress in halotolerant organisms.

  • DOI:10.1186/1746-1448-4-2 high salt concentrations in the environment Review supports high environmental salt as the stress context.
• compatible solutes mitigates osmotic stress METPO:2007407

  Compatible solutes are a mechanism for tolerating salt stress.

  • DOI:10.1093/femsre/fuy009 organic osmotic solutes Supports organic osmotic solutes as an osmoadaptation strategy.
• compatible-solute transport imports compatible solutes METPO:2000208

  Uptake systems import osmoprotectants that support halotolerance.

  • DOI:10.1016/j.csbj.2021.01.030 biosynthesis and/or uptake of compatible solutes Adds explicit source support for transport-mediated compatible-solute accumulation in bacterial salt-stress responses.
• compatible solutes contributes to stress protection RO:0002326

  Compatible solutes can stabilize cells under saline stress.

  • DOI:10.1139/cjm-2014-0233 stabilizers of intracellular proteins Haloalkaliphile review supports compatible solutes as stabilizing osmoprotectants; mechanism is shared with halotolerance.
• stress protection enables halotolerant RO:0002327

  Stress-protection mechanisms allow tolerance of salt exposure.

  • DOI:10.1371/journal.pone.0168818 allows microorganisms to cope with high salinities Supports osmoadaptation as a mechanism for growth under salt stress.
• osmotic stress increases compatible solute accumulation RO:0002213

  Osmotic stress drives accumulation of compatible solutes.

  • DOI:10.58088/07hg-r941 Compatible solutes are accumulated in response to osmotic stress; broad mechanistic claim across marine bacteria.
• salt-out strategy relies on compatible solute accumulation

  The salt-out osmoadaptation strategy relies on accumulation or de novo synthesis of compatible solutes.

  • DOI:10.1038/s41598-024-63581-z 'salt-out'/'low-salt-high-compatible-solute-in-cytoplasm' strategy relies on accumulation or de-novo synthesis of organic compatible solutes; directly supports halotolerant scope.
• ectABC operon enables ectoine biosynthesis RO:0002327

  The ectABC operon synthesizes ectoine de novo from aspartic acid.

  • DOI:10.58088/07hg-r941 Ectoine is synthesized de novo from aspartic acid via the ectABC operon; general bacterial mechanism.
• betA/betB enables glycine betaine biosynthesis RO:0002327

  betA and betB produce glycine betaine from environmental choline.

  • DOI:10.58088/07hg-r941 Glycine betaine is produced from environmental choline via betA and betB; canonical pathway edge, broadly applicable.
• ectoine biosynthesis produces compatible solutes METPO:2000202

  Ectoine biosynthesis yields a compatible solute supporting salt tolerance.

  • DOI:10.58088/07hg-r941 Ectoine is a compatible solute synthesized de novo via the ectABC operon.
• glycine betaine biosynthesis produces compatible solutes METPO:2000202

  Glycine betaine biosynthesis yields a compatible solute supporting salt tolerance.

  • DOI:10.58088/07hg-r941 Glycine betaine is produced from environmental choline and acts as a compatible solute.