lithoheterotrophic

Edge evidence

• lithoheterotrophic uses electron donor inorganic electron donor METPO:2000009

  Lithoheterotrophy uses inorganic compounds as energy-generating electron donors.

  • DOI:10.1016/B978-0-12-378630-2.00219-X oxidize inorganic atoms or molecules Supports inorganic chemical oxidation as lithotrophic energy metabolism.
• ferrous iron example of inorganic electron donor rdfs:subClassOf

  Fe(II) is an example inorganic electron donor for lithotrophic growth.

  • DOI:10.1038/s41598-021-81412-3 Fe(II) as the energy source Supports Fe(II) oxidation as the energy source in engineered lithoheterotrophy.
• inorganic electron donor feeds electrons into respiratory chain METPO:2007402

  Oxidation of inorganic donors feeds respiratory electron transport.

  • DOI:10.1016/j.bbabio.2008.09.008 membrane-bound electron transport chain Supports respiratory chains as energy-conserving redox systems.
• respiratory chain transfers electrons to molecular oxygen METPO:2007403

  Aerobic Fe(II)-oxidizing lithotrophy can reduce oxygen.

  • DOI:10.1038/s41598-021-81412-3 oxidation of Fe(II) coupled to the reduction of oxygen Supports oxygen reduction coupled to Fe(II) oxidation.
• respiratory chain produces ATP METPO:2000202

  Respiratory electron transport supports ATP synthesis.

  • DOI:10.1016/j.bbabio.2008.09.008 drives ATP synthesis Supports ATP synthesis from respiratory energy conservation.
• lithoheterotrophic uses carbon source organic carbon METPO:2000006

  Lithoheterotrophy uses organic compounds as carbon sources.

  • DOI:10.1038/s41598-021-81412-3 glucose as the sole carbon source Supports organic carbon use under Fe(II)-oxidizing lithoheterotrophic conditions.
• glucose example of organic carbon rdfs:subClassOf

  Glucose is an experimentally supported organic carbon source.

  • DOI:10.1038/s41598-021-81412-3 glucose as the sole carbon source Supports glucose as the organic carbon source in the engineered strain.
• organic carbon converted to precursor metabolites

  Organic carbon supplies biosynthetic precursors.

  • DOI:10.1038/s41598-021-81412-3 biomass precursors provided by glucose Supports glucose-derived carbon as a source of biomass precursors.
• precursor metabolites incorporated into biomass biolink:part_of

  Organic-carbon precursors are incorporated into cellular material.

  • DOI:10.1016/B978-012373944-5.00083-3 incorporation of a compound into biomass Supports assimilation of compounds into biomass.
• microaerobic conditions supports Fe(II) oxidation

  Microaerobic conditions support Fe(II)-oxidizing growth by limiting abiotic Fe(II) oxidation.

  • DOI:10.1038/s41598-021-81412-3 requiring microaerobic conditions because atmospheric O2 abiotically oxidizes Fe(II)
• ferrous iron oxidized in Fe(II) oxidation

  Ferrous iron is the substrate oxidized in the energy-yielding Fe(II) oxidation process.

  • DOI:10.1038/s41598-021-81412-3 the oxidation of Fe(II) coupled to the reduction of oxygen
• Fe(II) oxidation feeds electrons into respiratory chain METPO:2007402

  Fe(II) oxidation provides electrons for respiratory energy conservation.

  • DOI:10.1038/s41598-021-81412-3 Fe(II) oxidation provides energy while organic carbon serves primarily as the carbon source
• sulfide example of inorganic electron donor rdfs:subClassOf

  Sulfide is an inorganic electron donor for lithotrophic sulfur oxidation.

  • DOI:10.1038/s41467-025-56588-1 sulfide oxidation as lithotrophic energy metabolism in nitrate-reducing chemolithotrophs/heterotrophs
• sulfide:quinone oxidoreductase (SQR) oxidizes sulfide METPO:2000016

  SQR catalyzes oxidation/detoxification of sulfide as a sulfide-oxidation module.

  • DOI:10.1038/s41467-025-56588-1 a key enzyme that can catalyze sulfide detoxification in nitrate-reducing chemolithoautotrophs
• thiosulfate example of inorganic electron donor rdfs:subClassOf

  Thiosulfate is an inorganic sulfur electron donor for lithotrophic oxidation.

  • DOI:10.1038/s41467-025-56588-1 periplasmic sox gene clusters encoding for thiosulfate oxidation
• periplasmic Sox system oxidizes thiosulfate METPO:2000016

  The periplasmic Sox system encodes oxidation of thiosulfate.

  • DOI:10.1038/s41467-025-56588-1 periplasmic sox gene clusters encoding for thiosulfate oxidation
• conductive pili and c-type cytochromes enables direct interspecies electron transfer RO:0002327

  Conductive pili and outer-surface c-type cytochromes enable direct interspecies electron transfer.

  • DOI:10.3390/life14050591 direct interspecies electron transfer (DIET) via conductive pili and outer-surface c-type cytochromes