carboxydotrophic

Edge evidence

• carboxydotrophic uses energy substrate carbon monoxide

  Carboxydotrophs use carbon monoxide to support growth or metabolism.

  • DOI:10.1038/nrmicro1595 CO supports the growth and metabolism Supports carbon monoxide as an energy-supporting substrate.
• carbon monoxide dehydrogenase oxidizes carbon monoxide METPO:2000016

  CODH catalyzes carbon monoxide oxidation.

  • DOI:10.1038/nrmicro1595 CO dehydrogenase (CODH), to oxidize CO Supports CODH-mediated CO oxidation.
• molybdenum hydroxylase enzyme class for carbon monoxide dehydrogenase

  Aerobic CO oxidizers use a molybdenum hydroxylase CODH.

  • DOI:10.1038/nrmicro1595 use a molybdenum hydroxylase Supports molybdenum hydroxylase classification of aerobic CODH.
• carbon monoxide oxidized to carbon dioxide METPO:2007405

  CO oxidation yields carbon dioxide.

  • DOI:10.1007/s00775-018-1541-0 oxidation of CO to CO2 Supports CO-to-CO2 conversion by CODH.
• carbon monoxide dehydrogenase feeds electrons into respiratory chain METPO:2007402

  CO oxidation is coupled to respiratory electron transfer.

  • DOI:10.1111/j.1574-6968.1986.tb01858.x branched respiratory chain Supports respiratory-chain coupling in aerobic CO-utilizing bacteria.
• respiratory chain depends on CO-insensitive terminal oxidase RO:0002502

  CO-utilizing bacteria use a CO-insensitive terminal oxidase branch.

  • DOI:10.1111/j.1574-6968.1986.tb01858.x CO-insensitive terminal oxidase Supports terminal oxidase adaptation for CO metabolism.
• respiratory chain generates proton motive force biolink:produces

  Respiratory CO oxidation conserves energy as proton motive force.

  • DOI:10.1111/j.1574-6968.1986.tb01858.x pmf-driven reversed electron transfer Supports pmf involvement in aerobic carboxydotrophic energy metabolism.
• proton motive force drives formation of reduced pyridine nucleotides biolink:produces

  Reverse electron transfer can form reduced pyridine nucleotides.

  • DOI:10.1111/j.1574-6968.1986.tb01858.x formation of reduced pyridine nucleotides Supports pmf-driven reverse electron transfer output.
• Ni,Fe-carbon monoxide dehydrogenase has quality oxygen sensitivity

  Ni,Fe-CODHs are oxygen sensitive, restricting them to anaerobic carboxydotrophs.

  • DOI:10.1128/jb.00332-22 Ni,Fe-CODHs are noted as oxygen sensitive and associated with anaerobic carboxydotrophs.
• molybdenum hydroxylase has quality oxygen tolerance

  Cu,Mo-CODHs are O2-tolerant, enabling aerobic CO metabolism.

  • DOI:10.1128/jb.00332-22 Cu,Mo-CODHs are O2-tolerant (aerobic CO metabolism).
• cox operon encodes molybdenum hydroxylase biolink:encodes

  cox operons encode the coxS/coxM/coxL aerobic Mo-CODH subunits.

  • DOI:10.1128/jb.00332-22 Mo-CODH is encoded in cox operons that include coxS, coxM, and coxL.
• coo operon encodes Ni,Fe-carbon monoxide dehydrogenase biolink:encodes

  coo operons encode Ni,Fe-CODH plus accessory proteins for energy conservation.

  • DOI:10.1128/jb.00332-22 coo operons specifically encode CODH plus accessory proteins for energy conservation.
• CooA activates transcription of coo operon

  CO binding to CooA Fe(II)-heme allosterically activates coo operon transcription.

  • DOI:10.1128/jb.00332-22 CO binding to Fe(II)-heme allosterically activates promoter binding and RNAP recruitment of coo operons.
• RcoM regulates cox operon RO:0002211

  RcoM is a high-affinity CO sensor regulating aerobic coxMSL genes.

  • DOI:10.1128/jb.00332-22 RcoM regulates aerobic CO oxidation and was originally identified upstream of coxMSL genes.
• proton motive force powers ATP synthase

  The ion motive force generated by CO oxidation drives ATP synthase.

  • DOI:10.1186/s40643-023-00705-9 Generates an ion motive force that drives ATP synthesis.
• molybdenum hydroxylase coupled to reduction of dioxygen

  Mo-CODH-mediated CO oxidation is coupled to O2 reduction aerobically.

  • DOI:10.1101/2023.01.17.524042 Mo-CODH-mediated CO oxidation supports O2 reduction aerobically.