mixotrophic

METPO:1000652 · CLASS · REVIEWED

A trophic type in which an organism can use both organic and inorganic carbon sources for growth.

Mixotrophic dual carbon and energy use

DOI-backed graph linking organic carbon uptake, inorganic carbon fixation, light or chemical energy capture, and biomass production.

Mixotrophic dual carbon and energy use Interactive directed graph showing evidence-backed causal relationships for mixotrophic.

Edge evidence

  • mixotrophic uses carbon source organic carbon METPO:2000006

    Mixotrophs can use organic carbon as a carbon source.

    • DOI:10.1073/pnas.1305998110 organic carbon (C) for their C needs Supports organic carbon use as part of mixotrophic metabolism.
  • mixotrophic uses carbon source carbon dioxide METPO:2000006

    Mixotrophy can include inorganic carbon acquisition by CO2 fixation.

    • DOI:10.1073/pnas.1305998110 obtain its energy and carbon Supports combining autotrophic and heterotrophic carbon-acquisition modes.
  • dissolved organic matter supplies organic carbon

    Dissolved organic matter provides organic substrates in aquatic mixotrophy.

    • DOI:10.1128/AEM.01559-06 DOM, dissolved organic matter Figure legend identifies dissolved organic matter as a substrate pool in bacterial metabolic modes.
  • mixotrophic can use energy capture route phototrophic energy capture

    Some microbial mixotrophs supplement organic carbon use with light-harvesting energy systems.

    • DOI:10.1128/AEM.01559-06 rhodopsin and other pigment Review discusses pigment/rhodopsin-associated bacterial metabolic modes.
  • carbon dioxide fixed by CO2-fixation pathway METPO:2007404

    Inorganic carbon assimilation converts CO2 into cellular carbon.

    • DOI:10.1128/AEM.02473-10 autotrophic CO2 fixation Supports CO2 fixation as the inorganic-carbon assimilation process.
  • organic carbon incorporated into biomass biolink:part_of

    Organic carbon contributes to cell material in mixotrophic growth.

    • DOI:10.1016/B978-012373944-5.00083-3 incorporation of a compound into biomass Supports assimilatory conversion of organic compounds into biomass.
  • electron transport chain drives ATP synthesis

    Electron transport chain activity drives ATP synthesis.

    • DOI:10.1128/aem.00599-24 Complete ETC complexes and F-type ATPase support ETC-driven ATP synthesis.
  • proton motive force drives ATP synthesis

    Proton gradient drives ATP synthesis via ATP synthase.

    • DOI:10.1128/spectrum.02177-23 A proton gradient drives ATP synthesis (canonical bioenergetic edge).
  • phototrophic energy capture generates proton motive force biolink:produces

    Proton-pump rhodopsin photosystems generate a proton gradient.

    • DOI:10.1128/spectrum.02177-23 Proton-pump rhodopsin acts as a photosystem-independent proton pump creating a proton gradient.
  • RuBisCO enables Calvin-Benson-Bassham cycle RO:0002327

    RuBisCO enables the Calvin-Benson-Bassham cycle.

    • DOI:10.1128/aem.00599-24 MAGs encode Form II RuBisCO (rbcL/cbbM) and a full CBB cycle.
  • Calvin-Benson-Bassham cycle fixes carbon dioxide

    The Calvin-Benson-Bassham cycle fixes CO2 into organic carbon.

    • DOI:10.1128/aem.00599-24 A full CBB cycle is consistent with CO2 fixation potential.
  • organic matter limitation promotes switching to phototrophic energy capture

    When organic matter is limiting, mixotrophs switch to light-based energy and inorganic carbon use.

    • DOI:10.1128/AEM.01559-06 If organic matter is limiting, a mixotroph can switch to using light as an energy source and inorganic carbon as a carbon source.
  • light limitation promotes switching to organic carbon

    When light is limiting, mixotrophs switch back to degradation of organic substances.

    • DOI:10.1128/AEM.01559-06 As light gets limiting, the organism can switch back to degradation of organic substances.

Provenance

Source
METPO (2025-11-25)
Definition source
DOI:10.1128/AEM.01559-06

Parent traits (1)

Synonyms (1)

  • mixotroph RELATED_SYNONYM · metpo.owl

kg-microbe context

Matched 1 kg-microbe node via direct_metpo.

  • METPO:1000652 [-1.472, -3.019, -4.301, +1.004, …]

512-dim DeepWalkSkipGramEnsmallen embedding from kg-microbe (2026-04-25).

Nearest neighbors in embedding space

Top-8 cosine-similar METPO traits from the 2026-04-25 deepwalk (512-D).

Curation history

  1. · SEEDED_FROM_METPO · seed_from_metpo

    imported from data/raw/metpo.owl (CLASS)

  2. · CURATED_CAUSAL_GRAPH · Codex

    Added DOI-backed mixotrophy graph for dual organic/inorganic carbon use and light-associated energy capture.

  3. · GROUND_CAUSAL_PREDICATES · claude

    Grounded 2 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (METPO:2000006×2).

  4. · GROUND_CAUSAL_PREDICATES · claude

    Grounded 1 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (METPO:2007404×1).

  5. · GROUND_CAUSAL_NODES · claude

    Grounded 1 causal-node grounding field(s) via mappings/node_grounding.tsv (CHEBI:50860×1).

  6. · GROUND_CAUSAL_NODES · claude

    Grounded 1 causal-node grounding field(s) via mappings/node_grounding.tsv (METPO:1007501×1).

  7. · RETYPE_CAUSAL_NODES · claude

    Re-typed 1 causal-node node_type field(s) to align with CausalNodeTypeEnum semantics: biomass: BIOLOGICAL_PROCESS → CHEMICAL ×1.

  8. · GROUND_CAUSAL_NODES · claude

    Grounded 1 causal-node grounding field(s) via mappings/node_grounding.tsv (GO:0015977×1).

  9. · GROUND_CAUSAL_PREDICATES · claude

    Grounded 1 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (biolink:part_of×1).

  10. · ENRICH_CAUSAL_GRAPH · claude

    Added 7 evidence-backed generic edges (7 new nodes) from the deep-research report.

  11. · GROUND_CAUSAL_PREDICATES · claude

    Grounded 2 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (biolink:produces×1, RO:0002327×1).

  12. · GROUND_CAUSAL_NODES · claude

    Grounded 2 causal-node grounding field(s) via mappings/node_grounding.tsv (GO:0022900×1, UniProtKB:A0A075WF79×1).

  13. · GROUND_CAUSAL_NODES · claude

    Grounded 1 causal-node grounding field(s) via mappings/node_grounding.tsv (GO:0006754×1).