mixotrophic
METPO:1000652 · CLASS · REVIEWED
A trophic type in which an organism can use both organic and inorganic carbon sources for growth.
Mixotrophic dual carbon and energy use
Edge evidence
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mixotrophic
uses carbon source
organic carbon
METPO:2000006Mixotrophs can use organic carbon as a carbon source.
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DOI:10.1073/pnas.1305998110organic carbon (C) for their C needs
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mixotrophic
uses carbon source
carbon dioxide
METPO:2000006Mixotrophy can include inorganic carbon acquisition by CO2 fixation.
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DOI:10.1073/pnas.1305998110obtain its energy and carbon
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dissolved organic matter
supplies
organic carbon
Dissolved organic matter provides organic substrates in aquatic mixotrophy.
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DOI:10.1128/AEM.01559-06DOM, dissolved organic matter
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mixotrophic
can use energy capture route
phototrophic energy capture
Some microbial mixotrophs supplement organic carbon use with light-harvesting energy systems.
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DOI:10.1128/AEM.01559-06rhodopsin and other pigment
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carbon dioxide
fixed by
CO2-fixation pathway
METPO:2007404Inorganic carbon assimilation converts CO2 into cellular carbon.
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DOI:10.1128/AEM.02473-10autotrophic CO2 fixation
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organic carbon
incorporated into
biomass
biolink:part_ofOrganic carbon contributes to cell material in mixotrophic growth.
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DOI:10.1016/B978-012373944-5.00083-3incorporation of a compound into biomass
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electron transport chain
drives
ATP synthesis
Electron transport chain activity drives ATP synthesis.
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DOI:10.1128/aem.00599-24
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proton motive force
drives
ATP synthesis
Proton gradient drives ATP synthesis via ATP synthase.
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DOI:10.1128/spectrum.02177-23
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phototrophic energy capture
generates
proton motive force
biolink:producesProton-pump rhodopsin photosystems generate a proton gradient.
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DOI:10.1128/spectrum.02177-23
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RuBisCO
enables
Calvin-Benson-Bassham cycle
RO:0002327RuBisCO enables the Calvin-Benson-Bassham cycle.
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DOI:10.1128/aem.00599-24
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Calvin-Benson-Bassham cycle
fixes
carbon dioxide
The Calvin-Benson-Bassham cycle fixes CO2 into organic carbon.
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DOI:10.1128/aem.00599-24
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organic matter limitation
promotes switching to
phototrophic energy capture
When organic matter is limiting, mixotrophs switch to light-based energy and inorganic carbon use.
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DOI:10.1128/AEM.01559-06
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light limitation
promotes switching to
organic carbon
When light is limiting, mixotrophs switch back to degradation of organic substances.
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DOI:10.1128/AEM.01559-06
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Provenance
- Source
- METPO (2025-11-25)
- Definition source
- DOI:10.1128/AEM.01559-06
Parent traits (1)
Synonyms (1)
- mixotroph
kg-microbe context
Matched 1 kg-microbe node via direct_metpo.
METPO:1000652[-1.472, -3.019, -4.301, +1.004, …]
Nearest neighbors in embedding space
- physiology trophic type 0.879
- physiology hydrogenotrophic 0.873
- physiology carboxydotrophic 0.869
- physiology photolithoautotrophic 0.869
- physiology lithoautotrophic 0.838
- physiology photoorganoheterotrophic 0.823
- physiology chemoautotrophic 0.808
- physiology photolithotrophic 0.784
Curation history
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SEEDED_FROM_METPO · seed_from_metpo
imported from data/raw/metpo.owl (CLASS)
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CURATED_CAUSAL_GRAPH · Codex
Added DOI-backed mixotrophy graph for dual organic/inorganic carbon use and light-associated energy capture.
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GROUND_CAUSAL_PREDICATES · claude
Grounded 2 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (METPO:2000006×2).
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GROUND_CAUSAL_PREDICATES · claude
Grounded 1 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (METPO:2007404×1).
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GROUND_CAUSAL_NODES · claude
Grounded 1 causal-node grounding field(s) via mappings/node_grounding.tsv (CHEBI:50860×1).
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GROUND_CAUSAL_NODES · claude
Grounded 1 causal-node grounding field(s) via mappings/node_grounding.tsv (METPO:1007501×1).
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RETYPE_CAUSAL_NODES · claude
Re-typed 1 causal-node node_type field(s) to align with CausalNodeTypeEnum semantics: biomass: BIOLOGICAL_PROCESS → CHEMICAL ×1.
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GROUND_CAUSAL_NODES · claude
Grounded 1 causal-node grounding field(s) via mappings/node_grounding.tsv (GO:0015977×1).
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GROUND_CAUSAL_PREDICATES · claude
Grounded 1 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (biolink:part_of×1).
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ENRICH_CAUSAL_GRAPH · claude
Added 7 evidence-backed generic edges (7 new nodes) from the deep-research report.
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GROUND_CAUSAL_PREDICATES · claude
Grounded 2 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (biolink:produces×1, RO:0002327×1).
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·
GROUND_CAUSAL_NODES · claude
Grounded 2 causal-node grounding field(s) via mappings/node_grounding.tsv (GO:0022900×1, UniProtKB:A0A075WF79×1).
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·
GROUND_CAUSAL_NODES · claude
Grounded 1 causal-node grounding field(s) via mappings/node_grounding.tsv (GO:0006754×1).