Aerobic respiration

METPO:1000801 · CLASS · REVIEWED

A respiration in which molecular oxygen serves as the terminal electron acceptor in the electron transport chain, generating ATP through oxidative phosphorylation with water as the final product.

Aerobic respiration terminal oxidase mechanism

DOI-backed graph linking oxygen reduction, respiratory electron transport, proton motive force, and ATP synthesis.

Edge evidence

Aerobic respiration has mechanistic pathway electron transport chain
Aerobic respiration uses a membrane-bound respiratory electron transport chain.
- DOI:10.1016/j.bbabio.2008.09.008 membrane-bound electron transport chain Review describes respiration as redox reactions catalyzed by membrane-bound electron transport chains.
cytochrome c oxidase reduces molecular oxygen METPO:2000017
Terminal oxidase transfers electrons to molecular oxygen.
- DOI:10.1146/annurev.biophys.27.1.329 electron transfer from cytochrome c to molecular oxygen Supports oxygen as terminal electron acceptor for cytochrome c oxidase.
molecular oxygen reduced to water
Oxygen reduction forms water at the terminal oxidase.
- DOI:10.1146/annurev.biophys.27.1.329 reducing the latter to water Supports water as the product of terminal oxygen reduction.
electron transport chain generates proton motive force biolink:produces
Respiratory redox energy is conserved as an ion gradient.
- DOI:10.1016/j.bbabio.2008.09.008 generation of an electrochemical ion gradient Supports proton motive force generation by respiratory chains.
proton motive force regulates ATP synthase RO:0002211
The proton motive force powers ATP synthase.
- DOI:10.1146/annurev.biophys.27.1.329 employed by the F0F1-ATPase Supports ATP synthase use of the respiratory proton gradient.
ATP synthase produces ATP METPO:2000202
ATP synthase produces ATP during oxidative phosphorylation.
- DOI:10.1016/j.bbabio.2008.09.008 gradient across a coupling membrane that drives ATP synthesis Supports ATP synthesis driven by the respiratory ion gradient.

Provenance

Source: METPO (2025-11-25)
Author: Jed Dongjin Kim-Ozaeta
Definition source: DOI:10.1146/annurev.biophys.27.1.329

Parent traits (1)

respiration METPO:1000800

Synonyms (2)

Oxic respiration RELATED_SYNONYM · metpo.owl
Oxygen respiration RELATED_SYNONYM · metpo.owl

kg-microbe context

Matched 1 kg-microbe node via direct_metpo.

METPO:1000801 [-0.171, -2.146, -1.478, +1.150, …]

512-dim DeepWalkSkipGramEnsmallen embedding from kg-microbe (2026-04-25).

Nearest neighbors in embedding space

Top-8 cosine-similar METPO traits from the 2026-04-25 deepwalk (512-D).

metabolism Anaerobic respiration 0.959
metabolism dissimilatory sulfate reduction 0.959
metabolism anaerobic oxidation of methane 0.959
metabolism dissimilatory nitrate reduction to ammonium 0.959
metabolism dissimilatory metal reduction 0.959
metabolism dissimilatory manganese reduction 0.959
metabolism dissimilatory iron reduction 0.959
metabolism denitrification 0.959

Curation history

2026-05-05T01:35:46.911295+00:00 · SEEDED_FROM_METPO · seed_from_metpo
imported from data/raw/metpo.owl (CLASS)
2026-05-08T00:00:00-07:00 · ADDED_CAUSAL_GRAPH · codex
Added DOI-backed causal graph for oxygen reduction, proton motive force, and ATP synthesis in aerobic respiration.
2026-05-20T03:35:30Z · GROUND_CAUSAL_PREDICATES · claude
Grounded 1 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (METPO:2000202×1).
2026-05-23T08:21:49Z · GROUND_CAUSAL_PREDICATES · claude
Grounded 1 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (biolink:produces×1).
2026-05-24T04:13:19Z · RENAME_PREDICATE_LABELS · claude
Renamed 1 causal-edge predicate label(s) to align with existing groundings: drives → regulates ×1.
2026-05-24T04:13:21Z · GROUND_CAUSAL_PREDICATES · claude
Grounded 1 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (RO:0002211×1).
2026-05-24T04:41:03Z · GROUND_CAUSAL_NODES · claude
Grounded 1 causal-node grounding field(s) via mappings/node_grounding.tsv (METPO:1007500×1).
2026-05-24T05:05:14Z · GROUND_CAUSAL_NODES · claude
Grounded 2 causal-node grounding field(s) via mappings/node_grounding.tsv (UniProtKB:A0A075NZN5×1, UniProtKB:A0A415TT77×1).
2026-05-26T02:30:13Z · RETYPE_CAUSAL_NODES · claude
Re-typed 1 causal-node node_type field(s) to align with CausalNodeTypeEnum semantics: proton motive force: BIOLOGICAL_PROCESS → STATE ×1.
2026-06-16T06:30:56Z · GROUND_CAUSAL_PREDICATES · claude
Grounded 1 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (METPO:2000017×1).