respiration

METPO:1000800 · CLASS · REVIEWED

A metabolism that is characterized by the method of performing cellular respiration, distinguished primarily by the specific terminal electron acceptor utilized for producing cellular energy.

Respiration electron acceptor energy conservation

DOI-backed graph linking electron donors, terminal electron acceptors, membrane electron transport, proton motive force, and ATP synthesis.

Respiration electron acceptor energy conservation Interactive directed graph showing evidence-backed causal relationships for respiration.

Edge evidence

  • respiration uses electron flow from electron donor

    Respiration begins with reduced electron donors.

    • DOI:10.1016/j.bbabio.2008.09.008 free energy of a redox reaction Supports respiratory energy conservation from redox reactions.
  • electron donor transfers electrons to terminal electron acceptor METPO:2007403

    Electrons move from donors to terminal acceptors.

    • DOI:10.1016/j.bbabio.2008.09.008 electron transfer process Supports donor-to-acceptor electron flow in respiratory chains.
  • molecular oxygen example of terminal electron acceptor rdfs:subClassOf

    Oxygen is the terminal electron acceptor in aerobic respiration.

    • DOI:10.1128/mmbr.61.4.533-616.1997 oxygen as terminal electron acceptor Supports oxygen as a respiratory terminal acceptor.
  • nitrate example of terminal electron acceptor rdfs:subClassOf

    Nitrate is a representative anaerobic terminal electron acceptor.

    • DOI:10.1128/mmbr.61.4.533-616.1997 utilization of nitrate Supports nitrate use in anaerobic respiration.
  • membrane electron transport chain couples electron flow to proton motive force METPO:2007602

    Respiratory chains conserve redox energy as an ion gradient.

    • DOI:10.1016/j.bbabio.2008.09.008 generation of an electrochemical ion gradient Supports ion-gradient generation by membrane electron transport.
  • proton motive force regulates ATP synthase RO:0002211

    Proton motive force powers ATP synthase.

    • DOI:10.1016/j.bbabio.2008.09.008 drives ATP synthesis Supports ATP synthase as the downstream energy-conservation output.
  • ATP synthase produces ATP METPO:2000202

    ATP synthase produces ATP during respiration.

    • DOI:10.1016/j.bbabio.2008.09.008 ATP synthesis Supports ATP production from respiratory energy conservation.
  • respiratory Complex I (NADH:quinone oxidoreductase) contributes to proton motive force RO:0002326

    Complex I pumps protons during NADH oxidation/quinone reduction, building the proton motive force.

    • DOI:10.3390/ijms252413421 Complex I pumps four protons per pair of electrons, contributing to the formation of a proton motive force.
  • anoxic microsites controls terminal electron acceptor RO:0002211

    Anoxic microsites control the local availability and ordering of terminal electron acceptors.

    • DOI:10.1021/acsearthspacechem.3c00032 Microsites control the local availability and ordering of terminal electron acceptors (O2, NO3-, Fe(III), Mn(IV), SO4 2-).
  • oxygen depletion enables anaerobic respiration RO:0002327

    When O2 falls below physiological thresholds, cells shift to alternative acceptors and perform anaerobic respiration.

    • DOI:10.1021/acsearthspacechem.3c00032 When O2 falls below physiological thresholds, microorganisms shift to alternative electron acceptors and carry out anaerobic respiration.
  • anaerobic respiration subtype of respiration

    Anaerobic respiration is a form of respiration distinguished by its terminal electron acceptor.

    • DOI:10.1128/mmbr.61.4.533-616.1997 Review contrasts aerobic respiration with anaerobic use of alternative acceptors.

Provenance

Source
METPO (2025-11-25)
Author
Anthea Guo
Definition source
DOI:10.1016/j.bbabio.2008.09.008

Parent traits (1)

Synonyms (1)

  • pathways RELATED_SYNONYM · metpo.owl

kg-microbe context

Matched 1 kg-microbe node via direct_metpo.

  • METPO:1000800 [-0.241, -1.847, -1.014, +1.020, …]

512-dim DeepWalkSkipGramEnsmallen embedding from kg-microbe (2026-04-25).

Nearest neighbors in embedding space

Top-8 cosine-similar METPO traits from the 2026-04-25 deepwalk (512-D).

Curation history

  1. · SEEDED_FROM_METPO · seed_from_metpo

    imported from data/raw/metpo.owl (CLASS)

  2. · ADDED_CAUSAL_GRAPH · codex

    Added DOI-backed causal graph for donor-to-acceptor respiratory electron flow, membrane ion-gradient generation, and ATP synthesis.

  3. · GROUND_CAUSAL_PREDICATES · claude

    Grounded 1 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (METPO:2000202×1).

  4. · GROUND_CAUSAL_PREDICATES · claude

    Grounded 2 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (rdfs:subClassOf×2).

  5. · GROUND_CAUSAL_PREDICATES · claude

    Grounded 1 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (METPO:2007403×1).

  6. · RENAME_PREDICATE_LABELS · claude

    Renamed 1 causal-edge predicate label(s) to align with existing groundings: drives → regulates ×1.

  7. · GROUND_CAUSAL_PREDICATES · claude

    Grounded 1 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (RO:0002211×1).

  8. · GROUND_CAUSAL_NODES · claude

    Grounded 2 causal-node grounding field(s) via mappings/node_grounding.tsv (METPO:1007504×1, METPO:1007500×1).

  9. · GROUND_CAUSAL_NODES · claude

    Grounded 1 causal-node grounding field(s) via mappings/node_grounding.tsv (UniProtKB:A0A415TT77×1).

  10. · GROUND_CAUSAL_NODES · claude

    Grounded 2 causal-node grounding field(s) via mappings/node_grounding.tsv (CHEBI:17499×1, GO:0022900×1).

  11. · RETYPE_CAUSAL_NODES · claude

    Re-typed 1 causal-node node_type field(s) to align with CausalNodeTypeEnum semantics: proton motive force: BIOLOGICAL_PROCESS → STATE ×1.

  12. · GROUND_CAUSAL_PREDICATES · claude

    Grounded 1 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (METPO:2007602×1).

  13. · FIX_NODE_GROUNDING_CURIE · claude

    Overwrote 1 causal-node grounding(s) to corrected CURIEs (phase-2 id-label fix; verified vs OAK).

  14. · ENRICH_CAUSAL_GRAPH · claude

    Added 4 evidence-backed generic edges (4 new nodes) from the deep-research report.

  15. · GROUND_CAUSAL_PREDICATES · claude

    Grounded 3 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (RO:0002326×1, RO:0002211×1, RO:0002327×1).

  16. · GROUND_CAUSAL_NODES · claude

    Grounded 1 causal-node grounding field(s) via mappings/node_grounding.tsv (GO:0009061×1).