respiration
METPO:1000800 · CLASS · REVIEWED
A metabolism that is characterized by the method of performing cellular respiration, distinguished primarily by the specific terminal electron acceptor utilized for producing cellular energy.
Respiration electron acceptor energy conservation
Edge evidence
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respiration
uses electron flow from
electron donor
Respiration begins with reduced electron donors.
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DOI:10.1016/j.bbabio.2008.09.008free energy of a redox reaction
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electron donor
transfers electrons to
terminal electron acceptor
METPO:2007403Electrons move from donors to terminal acceptors.
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DOI:10.1016/j.bbabio.2008.09.008electron transfer process
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molecular oxygen
example of
terminal electron acceptor
rdfs:subClassOfOxygen is the terminal electron acceptor in aerobic respiration.
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DOI:10.1128/mmbr.61.4.533-616.1997oxygen as terminal electron acceptor
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nitrate
example of
terminal electron acceptor
rdfs:subClassOfNitrate is a representative anaerobic terminal electron acceptor.
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DOI:10.1128/mmbr.61.4.533-616.1997utilization of nitrate
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membrane electron transport chain
couples electron flow to
proton motive force
METPO:2007602Respiratory chains conserve redox energy as an ion gradient.
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DOI:10.1016/j.bbabio.2008.09.008generation of an electrochemical ion gradient
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proton motive force
regulates
ATP synthase
RO:0002211Proton motive force powers ATP synthase.
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DOI:10.1016/j.bbabio.2008.09.008drives ATP synthesis
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ATP synthase
produces
ATP
METPO:2000202ATP synthase produces ATP during respiration.
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DOI:10.1016/j.bbabio.2008.09.008ATP synthesis
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respiratory Complex I (NADH:quinone oxidoreductase)
contributes to
proton motive force
RO:0002326Complex I pumps protons during NADH oxidation/quinone reduction, building the proton motive force.
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DOI:10.3390/ijms252413421
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anoxic microsites
controls
terminal electron acceptor
RO:0002211Anoxic microsites control the local availability and ordering of terminal electron acceptors.
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DOI:10.1021/acsearthspacechem.3c00032
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oxygen depletion
enables
anaerobic respiration
RO:0002327When O2 falls below physiological thresholds, cells shift to alternative acceptors and perform anaerobic respiration.
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DOI:10.1021/acsearthspacechem.3c00032
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anaerobic respiration
subtype of
respiration
Anaerobic respiration is a form of respiration distinguished by its terminal electron acceptor.
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DOI:10.1128/mmbr.61.4.533-616.1997
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Provenance
- Source
- METPO (2025-11-25)
- Author
- Anthea Guo
- Definition source
- DOI:10.1016/j.bbabio.2008.09.008
Parent traits (1)
Children (3)
Synonyms (1)
- pathways
kg-microbe context
Matched 1 kg-microbe node via direct_metpo.
METPO:1000800[-0.241, -1.847, -1.014, +1.020, …]
Nearest neighbors in embedding space
- metabolism dissimilatory iron reduction 0.968
- metabolism denitrification 0.968
- metabolism dissimilatory sulfate reduction 0.968
- metabolism dissimilatory nitrate reduction to ammonium 0.968
- metabolism anaerobic oxidation of methane 0.968
- metabolism dissimilatory manganese reduction 0.968
- metabolism dissimilatory metal reduction 0.968
- metabolism Anaerobic respiration 0.968
Curation history
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SEEDED_FROM_METPO · seed_from_metpo
imported from data/raw/metpo.owl (CLASS)
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ADDED_CAUSAL_GRAPH · codex
Added DOI-backed causal graph for donor-to-acceptor respiratory electron flow, membrane ion-gradient generation, and ATP synthesis.
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GROUND_CAUSAL_PREDICATES · claude
Grounded 1 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (METPO:2000202×1).
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GROUND_CAUSAL_PREDICATES · claude
Grounded 2 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (rdfs:subClassOf×2).
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GROUND_CAUSAL_PREDICATES · claude
Grounded 1 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (METPO:2007403×1).
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RENAME_PREDICATE_LABELS · claude
Renamed 1 causal-edge predicate label(s) to align with existing groundings: drives → regulates ×1.
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GROUND_CAUSAL_PREDICATES · claude
Grounded 1 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (RO:0002211×1).
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GROUND_CAUSAL_NODES · claude
Grounded 2 causal-node grounding field(s) via mappings/node_grounding.tsv (METPO:1007504×1, METPO:1007500×1).
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GROUND_CAUSAL_NODES · claude
Grounded 1 causal-node grounding field(s) via mappings/node_grounding.tsv (UniProtKB:A0A415TT77×1).
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GROUND_CAUSAL_NODES · claude
Grounded 2 causal-node grounding field(s) via mappings/node_grounding.tsv (CHEBI:17499×1, GO:0022900×1).
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RETYPE_CAUSAL_NODES · claude
Re-typed 1 causal-node node_type field(s) to align with CausalNodeTypeEnum semantics: proton motive force: BIOLOGICAL_PROCESS → STATE ×1.
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GROUND_CAUSAL_PREDICATES · claude
Grounded 1 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (METPO:2007602×1).
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FIX_NODE_GROUNDING_CURIE · claude
Overwrote 1 causal-node grounding(s) to corrected CURIEs (phase-2 id-label fix; verified vs OAK).
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ENRICH_CAUSAL_GRAPH · claude
Added 4 evidence-backed generic edges (4 new nodes) from the deep-research report.
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GROUND_CAUSAL_PREDICATES · claude
Grounded 3 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (RO:0002326×1, RO:0002211×1, RO:0002327×1).
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GROUND_CAUSAL_NODES · claude
Grounded 1 causal-node grounding field(s) via mappings/node_grounding.tsv (GO:0009061×1).