fermentative hydrogen production

traitmech:000109 · CLASS · REVIEWED

A fermentation in which an organism disposes of excess reducing equivalents by producing molecular hydrogen (H2), typically via hydrogenases acting on reduced ferredoxin or formate.

Fermentative H2 production disposes of excess reducing equivalents

Evidence-backed causal sketch linking hydrogenase activity on reduced ferredoxin or formate to molecular hydrogen production as a redox-balancing fermentation output.

Fermentative H2 production disposes of excess reducing equivalents Interactive directed graph showing evidence-backed causal relationships for fermentative hydrogen production.

Edge evidence

  • fermentative hydrogen production participates in fermentation biolink:participates_in

    Fermentative H2 production is a class of fermentation metabolism.

    • DOI:10.3389/fmicb.2021.703525 Energy-conservation review supports H2 production as a redox-balancing fermentation output via hydrogenases.
  • fermentative hydrogen production produces molecular hydrogen METPO:2000202

    Hydrogenases produce H2 to regenerate oxidized cofactors.

    • DOI:10.1016/S0360-3199(02)00131-3 Hallenbeck & Benemann review biological hydrogen production, including dark fermentative H2 generation.
  • [FeFe] hydrogenase produces molecular hydrogen METPO:2000202

    [FeFe]-hydrogenases are producers of H2 in dark fermentation.

    • DOI:10.3390/en16083321 [FeFe]-hydrogenases explicitly noted as producers of H2 in dark fermentation.
  • low H2 partial pressure stimulates fermentative hydrogen production

    Low ambient H2 partial pressure stimulates H2 formation.

    • DOI:10.1128/aem.00634-23 Low ambient H2 stimulated hydrogen (H2) formation; likely broadly relevant across fermenters.
  • high H2 partial pressure inhibits fermentative hydrogen production RO:0002212

    High ambient H2 partial pressure inhibits H2 formation (product feedback).

    • DOI:10.1128/aem.00634-23 High H2 inhibited H2 formation.
  • pH affects fermentative hydrogen production

    pH affects the activity of hydrogenase enzymes and thus dark fermentative H2 yield.

    • DOI:10.3390/en16083321 pH affects the activity of hydrogenase enzymes and dark fermentative H2 yield.

Provenance

Source
METPO (2025-11-25)
Definition source
DOI:10.3389/fmicb.2021.703525

Parent traits (1)

Synonyms (1)

  • biohydrogen production RELATED_SYNONYM · DOI:10.1016/S0360-3199(02)00131-3

kg-microbe context

Matched 1 kg-microbe node via parent_proxy.

  • METPO:1002005 [-0.758, -6.428, +3.551, +10.454, …]

512-dim DeepWalkSkipGramEnsmallen embedding from kg-microbe (2026-04-25).

Nearest neighbors in embedding space

Top-8 cosine-similar METPO traits from the 2026-04-25 deepwalk (512-D).

Curation history

  1. · PROPOSED_FROM_RESEARCH · claude

    Proposed candidate METABOLISM trait (fermentative hydrogen production); round 2, sub-variant of the existing Fermentation class (METPO:1002005).

  2. · CURATED_CAUSAL_GRAPH · claude

    Added evidence-backed causal graph (fermentative H2 production) with GO/CHEBI node groundings and METPO/biolink predicate groundings; promoted PROPOSED to REVIEWED.

  3. · ENRICH_CAUSAL_GRAPH · claude

    Added 4 evidence-backed generic edges (4 new nodes) from the deep-research report.

  4. · GROUND_CAUSAL_PREDICATES · claude

    Grounded 2 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (METPO:2000202×1, RO:0002212×1).

  5. · GROUND_CAUSAL_NODES · claude

    Grounded 1 causal-node grounding field(s) via mappings/node_grounding.tsv (PATO:0001842×1).