carotenoid pigmentation

METPO:1003031 · CLASS · REVIEWED

A pigmentation phenotype caused by microbial production and accumulation of carotenoid pigments.

Carotenoid pigmentation crt-pathway mechanism

Evidence-backed causal sketch linking bacterial carotenoid pigmentation to isoprenoid precursors, crt enzymes, conjugated carotenoids, and yellow-orange-red visible color.

Carotenoid pigmentation crt-pathway mechanism Interactive directed graph showing evidence-backed causal relationships for carotenoid pigmentation.

Edge evidence

  • isoprenoid precursors feed into carotenoid biosynthesis

    Isoprenoid precursors provide substrate for carotenoid production.

    • DOI:10.1016/j.gene.2004.11.038 isoprenoid precursor biosynthesis Supports isoprenoid precursor biosynthesis as a major step in eubacterial carotenoid pathways.
  • Crt enzymes catalyzes carotenoid biosynthesis biolink:catalyzes

    Crt gene products catalyze bacterial carotenoid biosynthetic reactions.

    • DOI:10.1080/1040841X.2025.2526423 crt genes ... reactions they catalyze Supports Crt enzymes as pathway catalysts.
  • carotenoid biosynthesis produces conjugated carotenoids METPO:2000202

    Carotenoid biosynthesis produces conjugated carotenoid pigments.

    • DOI:10.1080/1040841X.2025.2526423 biosynthesis pathways of bacterial carotenoids Supports bacterial carotenoid biosynthesis as the source of carotenoid pigments.
  • conjugated carotenoids causes yellow-orange-red color biolink:causes

    Conjugated carotenoids absorb visible light and produce yellow-orange-red pigmentation.

    • DOI:10.1080/1040841X.2025.2526423 red, pink, orange, and yellow pigmentation in bacteria Supports carotenoids as color determinants for this pigment class.
  • yellow-orange-red color manifests as carotenoid pigmentation METPO:2007400

    Yellow-orange-red visible color manifests carotenoid pigmentation.

    • DOI:10.1080/1040841X.2025.2526423 responsible for the red, pink, orange, and yellow pigmentation Supports the trait-level mapping from carotenoid chemistry to pigmentation.
  • phytoene synthase converts phytoene

    Phytoene synthase condenses prenyl diphosphate (GFDP) to form phytoene.

    • DOI:10.3390/molecules29174235 Through the catalytic action of phytoene synthase, GFDP undergoes condensation to form phytoene.
  • phytoene is substrate for phytoene desaturase

    Phytoene is dehydrogenated by phytoene desaturase en route to lycopene.

    • DOI:10.3390/molecules29174235 Phytoene is further dehydrogenated by dehydrogenase to generate phytofluene, which is subsequently converted into lycopene.
  • phytoene desaturase produces lycopene METPO:2000202

    Phytoene desaturase converts phytoene (via phytofluene) to lycopene.

    • DOI:10.3390/molecules29174235 Phytoene is further dehydrogenated... which is subsequently converted into lycopene.
  • lycopene cyclases converts cyclic carotenes

    Lycopene cyclases cyclize lycopene into alpha-, epsilon-, and beta-carotene.

    • DOI:10.3390/molecules29174235 The cyclization of lycopene... lead[s] to the formation of alpha-carotene, epsilon-carotene, and beta-carotene under the catalysis of various lycopene cyclases.
  • lycopene is substrate for lycopene cyclases

    Lycopene is the substrate cyclized by lycopene cyclases.

    • DOI:10.3390/molecules29174235 The cyclization of lycopene... under the catalysis of various lycopene cyclases.
  • cyclic carotenes is a conjugated carotenoids rdfs:subClassOf

    Cyclic carotenes are conjugated carotenoid pigments contributing to coloration.

    • DOI:10.3390/molecules29174235 Cyclic carotenes (alpha-/epsilon-/beta-carotene) are conjugated carotenoid pigment products of the pathway.

Provenance

Source
METPO (2025-11-25)
Definition source
DOI:10.1080/1040841X.2025.2526423

Parent traits (1)

Synonyms (1)

  • Pigment_carotenoid RELATED_SYNONYM · metpo.owl

kg-microbe context

Matched 1 kg-microbe node via direct_metpo.

  • METPO:1003031 [-2.345, -1.877, -1.987, -1.228, …]

512-dim DeepWalkSkipGramEnsmallen embedding from kg-microbe (2026-04-25).

Nearest neighbors in embedding space

Top-8 cosine-similar METPO traits from the 2026-04-25 deepwalk (512-D).

Curation history

  1. · SEEDED_FROM_METPO · seed_from_metpo

    imported from data/raw/metpo.owl (CLASS)

  2. · CURATED_WITH_LITERATURE · codex

    Added DOI-backed definition and causal graph for isoprenoid precursors, Crt enzymes, carotenoid biosynthesis, conjugated carotenoids, and visible pigmentation.

  3. · GROUND_CAUSAL_PREDICATES · claude

    Grounded 1 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (METPO:2000202×1).

  4. · GROUND_CAUSAL_PREDICATES · claude

    Grounded 2 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (biolink:catalyzes×1, biolink:causes×1).

  5. · GROUND_CAUSAL_PREDICATES · claude

    Grounded 1 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (METPO:2007400×1).

  6. · GROUND_CAUSAL_NODES · claude

    Grounded 1 causal-node grounding field(s) via mappings/node_grounding.tsv (GO:0016117×1).

  7. · ENRICH_CAUSAL_GRAPH · claude

    Added 6 evidence-backed generic edges (6 new nodes) from the deep-research report.

  8. · GROUND_CAUSAL_PREDICATES · claude

    Grounded 2 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (METPO:2000202×1, rdfs:subClassOf×1).

  9. · GROUND_CAUSAL_NODES · claude

    Grounded 2 causal-node grounding field(s) via mappings/node_grounding.tsv (CHEBI:15948×1, CHEBI:35163×1).

  10. · GROUND_CAUSAL_NODES · claude

    Grounded 2 causal-node grounding field(s) via mappings/node_grounding.tsv (UniProtKB:A0A023WN98×1, UniProtKB:A0A060JDC8×1).