red pigmented

Edge evidence

• prodiginine biosynthesis includes PigC/RedH condensation biolink:has_part

  Prodiginine biosynthesis culminates in PigC/RedH-catalyzed condensation.

  • DOI:10.1038/nrmicro1531 culminating in the PigC/RedH catalysed condensation Supports PigC/RedH condensation as a key step in prodiginine biosynthesis.
• PigC/RedH condensation produces prodigiosin METPO:2000202

  PigC/RedH condensation produces prodigiosin or related prodiginines.

  • DOI:10.1038/nrmicro1531 to form prodigiosin Supports prodigiosin as a pathway product.
• prodigiosin causes visible red color biolink:causes

  Prodigiosin causes red colony pigmentation in representative bacteria.

  • DOI:10.1021/acs.chemrev.6b00024 bright red pigment prodigiosin Supports prodigiosin as a red pigment.
• visible red color manifests as red pigmented METPO:2007400

  Visible red color manifests the red-pigmented phenotype.

  • DOI:10.1038/nrmicro1531 red-pigmented prodiginines Supports trait-level red pigmentation from prodiginines.
• prodiginine biosynthetic gene cluster (Pig/Red) enables red pigmented RO:0002327

  Prodiginine biosynthetic gene clusters (Pig/Red) encode the pathway producing red tripyrrole pigments, enabling the red-pigmented phenotype across taxa.

  • DOI:10.3390/microorganisms11122920 Prodiginines are red tripyrrole pigments genetically encoded by variable gene clusters (Pig in Serratia, Red in Streptomyces); broad cross-taxon mechanism.
• prodiginine biosynthetic gene cluster (Pig/Red) has part PigC ligase

  The pig gene cluster encodes the PigC ligase that catalyzes the final condensation step.

  • DOI:10.3389/fmicb.2024.1412776 The ligase encoded by pigC is the key enzyme that links MAP and MBC.
• PigC ligase catalyzes PigC/RedH condensation biolink:catalyzes

  PigC ligase catalyzes the condensation of MAP and MBC that forms prodigiosin.

  • DOI:10.3389/fmicb.2024.1412776 The ligase encoded by pigC is the key enzyme that links MAP and MBC to form prodigiosin.
• CpxA/CpxR two-component system represses transcription of prodiginine biosynthetic gene cluster (Pig/Red)

  Activation of the CpxA/CpxR system triggers a phosphorylation cascade that inhibits transcription of pig gene clusters, reducing prodigiosin and red pigmentation.

  • DOI:10.3389/fmicb.2024.1412776 Activated CpxA triggers a phosphorylation cascade that inhibits transcription of pig gene clusters and reduces PG production.
• carotenoid biosynthesis (phytoene synthase pathway) produces lycopene METPO:2000202

  Phytoene synthase condenses two GGPP to phytoene, then desaturation/isomerization yields the red pigment lycopene.

  • DOI:10.3390/microorganisms11122920 Two GGPP molecules condensed by phytoene synthase form phytoene, ultimately yielding lycopene, a red-colored pigment.
• lycopene causes visible red color biolink:causes

  Lycopene is a red-colored carotenoid pigment that confers red color, providing a carotenoid route to red pigmentation.

  • DOI:10.3390/microorganisms11122920 Lycopene described explicitly as 'a red-colored pigment'.